Evidence map›Paper›PMID 27879679›Full record

ArticleInternational journal of molecular sciences2016

Hydrostatin-TL1, an Anti-Inflammatory Active Peptide from the Venom Gland of Hydrophis cyanocinctus in the South China Sea.

Ningyuan Wang, Yan Huang, An Li, Hailong Jiang, Jie Wang, Jianzhong Li, Lei Qiu, Ka Li, Yiming Lu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Prospecting for candidate molecules fromThe journal of venomous animals and toxins including tropical diseases · 2022
    Article
  7. Antiinflammatory peptides: current knowledge and promising prospects.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ningyuan WangSchool of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China. wangningyuan1230@163.com.
Yan HuangDepartment of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. huangyantiger2005@163.com.
An LiDepartment of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. ezioleon@foxmail.com.
Hailong JiangDepartment of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. jhlong1986@163.com.
Jie WangDepartment of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. wj890801@126.com.
Jianzhong LiDepartment of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. lijianzhong1234@hotmail.com.
Lei QiuDepartment of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. qlcong021@163.com.
Ka LiBiomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China. karllee75@hotmail.com.
Yiming LuDepartment of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. bluesluyi@sina.com.
Second Military Medical University · CNFujian University of Traditional Chinese Medicine · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor necrosis factor (TNF)-α is a pleiotropic cytokine with intense pro-inflammatory and immunomodulatory properties, and anti-TNF-α biologics are effective therapies for various inflammatory diseases such as inflammatory bowel disease (IBD) and sepsis. Snake venom, as a traditional Chinese medicine, has been used in the treatment of inflammatory diseases in China for centuries. In this research, we constructed a venom gland T7 phage display library of the sea snake

Indexed as

Acute DiseaseAnimalsAnti-Inflammatory AgentsCell LineCell SurvivalColitisColubridaeDextran SulfateElapid VenomsExtracellular Signal-Regulated MAP KinasesFibroblastsGene Expression RegulationHEK293 CellsHumansLipopolysaccharidesMiceAnti-Inflammatory AgentsDextran SulfateElapid VenomsExtracellular Signal-Regulated MAP Kinaseshydrostatin-TL1 peptide, Hydrophis cyanocinctusLipopolysaccharidesOligopeptidesp38 Mitogen-Activated Protein KinasesPeptide LibraryReceptors, Tumor Necrosis Factor, Type IReptilian ProteinsSnake VenomsTnfrsf1a protein, mouseTumor Necrosis Factor-alphaanti-inflammatoryH-TL1Hydrophis cyanocinctusinflammatory bowel diseasesTNF-α

Identifiers

PMID27879679
PMCPMC5133935
OpenAlexW2554530896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.