ArticleGenetics2017
The Effects of Migration and Assortative Mating on Admixture Linkage Disequilibrium.
Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- No evidence for disassortative mating based on HLA in a small-scale, endogamous population.bioRxiv : the preprint server for biology · 2025Article
- Interpreting SNP heritability in admixed populations.Genetics · 2025Article
- Nested Admixture During and After the Trans-Atlantic Slave Trade on the Island of São Tomé.Molecular biology and evolution · 2025Article
- Differentiating mechanism from outcome for ancestry-assortative mating in admixed human populations.Genetics · 2025Article
- Interpreting SNP heritability in admixed populations.bioRxiv : the preprint server for biology · 2025Article
- Differentiating mechanism from outcome for ancestry-assortative mating in admixed human populations.bioRxiv : the preprint server for biology · 2024Article
- Interpreting population- and family-based genome-wide association studies in the presence of confounding.PLoS biology · 2024Article
- Article
- Article
- On the number of genealogical ancestors tracing to the source groups of an admixed population.Genetics · 2023Article
- A genetic and linguistic analysis of the admixture histories of the islands of Cabo Verde.eLife · 2023Article
- Interpreting population and family-based genome-wide association studies in the presence of confounding.bioRxiv : the preprint server for biology · 2023Article
- Rapid Evolution of the Fine-scale Recombination Landscape in Wild House Mouse (Mus musculus) Populations.Molecular biology and evolution · 2023Article
- Sex-biased admixture and assortative mating shape genetic variation and influence demographic inference in admixed Cabo Verdeans.G3 (Bethesda, Md.) · 2022Article
- Simultaneous inference of parental admixture proportions and admixture times from unphased local ancestry calls.American journal of human genetics · 2022Article
- Assortative mating enhances postzygotic barriers to gene flow via ancestry bundling.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Human genetic admixture through the lens of population genomics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome.Comprehensive Physiology · 2021Article
- Skin deep: The decoupling of genetic admixture levels from phenotypes that differed between source populations.American journal of physical anthropology · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Statistical models in medical and population genetics typically assume that individuals assort randomly in a population. While this simplifies model complexity, it contradicts an increasing body of evidence of nonrandom mating in human populations. Specifically, it has been shown that assortative mating is significantly affected by genomic ancestry. In this work, we examine the effects of ancestry-assortative mating on the linkage disequilibrium between local ancestry tracks of individuals in an admixed population. To accomplish this, we develop an extension to the Wright-Fisher model that allows for ancestry-based assortative mating. We show that ancestry-assortment perturbs the distribution of local ancestry linkage disequilibrium (LAD) and the variance of ancestry in a population as a function of the number of generations since admixture. This assortment effect can induce errors in demographic inference of admixed populations when methods assume random mating. We derive closed form formulae for LAD under an assortative-mating model with and without migration. We observe that LAD depends on the correlation of global ancestry of couples in each generation, the migration rate of each of the ancestral populations, the initial proportions of ancestral populations, and the number of generations since admixture. We also present the first direct evidence of ancestry-assortment in African Americans and examine LAD in simulated and real admixed population data of African Americans. We find that demographic inference under the assumption of random mating significantly underestimates the number of generations since admixture, and that accounting for assortative mating using the patterns of LAD results in estimates that more closely agrees with the historical narrative.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.