Evidence map›Paper›PMID 27879287›Full record

ArticleThe Journal of experimental medicine2016

Tissue-specific programming of memory CD8 T cell subsets impacts protection against lethal respiratory virus infection.

Georges Abboud, Pritesh Desai, Farhad Dastmalchi, Jessica Stanfield, Vikas Tahiliani, Tarun E Hutchinson, Shahram Salek-Ardakani

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. CD8Frontiers in immunology · 2021
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Dynamics of Tissue-Specific CD8Journal of virology · 2018
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Long-lived tissue resident HIV-1 specific memory CD8Journal of controlled release : official journal of the Controlled Release Society · 2017
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Georges AbboudDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611.ORCID 0000-0003-0353-2515
Pritesh DesaiDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611.ORCID 0000-0002-4697-9475
Farhad DastmalchiDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611.ORCID 0000-0003-0665-0824
Jessica StanfieldDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611.ORCID 0000-0003-4543-1392
Vikas TahilianiDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611.
Tarun E HutchinsonDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611.ORCID 0000-0002-9175-7222
Shahram Salek-ArdakaniDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611 ssalek@ufl.edu.ORCID 0000-0002-2336-8452
University of Florida · US

Funding

IMMUNOLOGIC/GENETIC MECHANISMS IN RHEUMATIC DISEASEST32AR007603 · NIAMS · UNIVERSITY OF FLORIDA · PI REEVES, WESTLEY H · 1998 to 2014
$2.2M
LIGHT_HVEM_BTLA axis in protective anti_viral immunityR01AI087734 · NIAID · UNIVERSITY OF FLORIDA · PI SALEK-ARDAKANI, SHAHRAM · 2011 to 2015
$1.6M
NIAID NIH HHS HHSN272201300006CNIAID NIH HHS R01 AI087734NIAMS NIH HHS T32 AR007603
6 · The paper itself

Abstract

How tissue-specific anatomical distribution and phenotypic specialization are linked to protective efficacy of memory T cells against reinfection is unclear. Here, we show that lung environmental cues program recently recruited central-like memory cells with migratory potentials for their tissue-specific functions during lethal respiratory virus infection. After entering the lung, some central-like cells retain their original CD27

Indexed as

Immunologic MemoryAnimalsCD8-Positive T-LymphocytesFemaleMiceMice, TransgenicPulmonary AlveoliRespiratory Tract InfectionsRespirovirusRespirovirus Infections

Identifiers

PMID27879287
PMCPMC5154936
OpenAlexW2553969326

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.