Evidence map›Paper›PMID 27879206›Full record

ArticleeLife2016

Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in

Subhendu Roy Choudhury, Anand K Singh, Tina McLeod, Marco Blanchette, Boyun Jang, Paul Badenhorst, Aditi Kanhere, Saverio Brogna

Open access · goldAbstract read
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. RNA binding proteins in cardiovascular development and disease.Current topics in developmental biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Subhendu Roy ChoudhurySchool of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Anand K SinghSchool of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Tina McLeodSchool of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Marco BlanchetteStowers Institute for Medical Research, Kansas city, United States.
Boyun JangInstitute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom.
Paul BadenhorstInstitute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom.
Aditi KanhereSchool of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Saverio BrognaSchool of Biosciences, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0001-7063-4381
University of Birmingham · GBMax Planck Institute for Developmental Biology · DEAsan Medical Center · KRNIHR Birmingham Biomedical Research Centre · GBStowers Institute for Medical Research · US

Funding

Wellcome TrustWellcome Trust 9340/Z/09/Z
6 · The paper itself

Abstract

Although it is currently understood that the exon junction complex (EJC) is recruited on spliced mRNA by a specific interaction between its central protein, eIF4AIII, and splicing factor CWC22, we found that eIF4AIII and the other EJC core proteins Y14 and MAGO bind the nascent transcripts of not only intron-containing but also intronless genes on

Indexed as

RNA SplicingAnimalsCell FractionationCells, CulturedChromosome MappingDrosophila melanogasterDrosophila ProteinsEukaryotic Initiation Factor-4AExonsIntronsNuclear ProteinsPolytene ChromosomesProtein BindingRNA-Binding ProteinsRNA, MessengerRNA PrecursorsDrosophila ProteinsEukaryotic Initiation Factor-4AMago protein, DrosophilaNuclear ProteinsRNA-Binding ProteinsRNA, MessengerRNA Precursorstsu protein, DrosophilachromosomesD. melanogasterEJCgenessplicingtranslation

Identifiers

PMID27879206
PMCPMC5158136
OpenAlexW2554144735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.