Evidence map›Paper›PMID 27879053›Full record

ArticleChemMedChem2016

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists.

Christelle Doebelin, Rémi Patouret, Ruben D Garcia-Ordonez, Mi Ra Chang, Venkatasubramanian Dharmarajan, Dana S Kuruvilla, Scott J Novick, Li Lin, Michael D Cameron, Patrick R Griffin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. An Efficient Approach to 2-CFMolecules (Basel, Switzerland) · 2021
    Article
  4. Development of Inhibitors againstJournal of medicinal chemistry · 2019
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Christelle DoebelinDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Rémi PatouretDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Ruben D Garcia-OrdonezDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Mi Ra ChangDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Venkatasubramanian DharmarajanDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Dana S KuruvillaDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Scott J NovickDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Li LinDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Michael D CameronDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Patrick R GriffinDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Theodore M KameneckaDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.
Scripps Research Institute · US

Funding

Development of RORbeta-selective modulators as in vivo probesR01MH108173 · NIMH · SCRIPPS FLORIDA · PI GRIFFIN, PATRICK ROBERT, KAMENECKA, THEODORE M · 2015 to 2017
$1.4M
Optimization of RORgamma-specific agonists as immune activators for a new immunotherapy approach for cancerR01CA206493 · NCI · SCRIPPS FLORIDA · PI GRIFFIN, PATRICK ROBERT, KAMENECKA, THEODORE M · 2016 to 2018
$1.3M
NCI NIH HHS R01 CA206493NIMH NIH HHS R01 MH108173
6 · The paper itself

Abstract

The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (T

Indexed as

Binding SitesDrug Inverse AgonismHEK293 CellsHumansIndolesInterleukin-17Molecular Docking SimulationPromoter Regions, GeneticProtein BindingProtein Structure, TertiaryReceptors, Retinoic AcidRetinoic Acid Receptor gammaStructure-Activity RelationshipTh17 CellsIndolesindolineInterleukin-17Receptors, Retinoic AcidRetinoic Acid Receptor gammacancer immunotherapyN-arylsulfonyl indolinesnuclear receptorsRORγ agonists

Identifiers

PMID27879053
PMCPMC5158182
OpenAlexW2549371705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.