ArticleMolecular plant pathology2018
Differential expression of cucumber RNA-dependent RNA polymerase 1 genes during antiviral defence and resistance.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Molecular Mechanisms Underlying Cucumber Resistance to Cucumber Green Mottle Mosaic Virus: From Host-Virus Interactions to Precision Breeding Strategies.International journal of molecular sciences · 2026Review
- CsRDR1b and CsRDR1c genes in Cucumis sativus are crucial for plant defense against virus and oomycete co-infection.Scientific reports · 2026Article
- Genome-wide association studies to assess genetic factors controlling cucumber resistance to CABYV and CMV in crop fields and the attractiveness for theirHorticulture research · 2025Article
- Genetic Dissection of ToLCNDV Resistance in Resistant Sources ofInternational journal of molecular sciences · 2024Article
- Salicylic acid and RNA interference mediate antiviral immunity of plant stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Rapid defense mechanism suppression during viral- oomycete disease complex formation.Frontiers in plant science · 2023Article
- Transcriptomic alterations in the sweet orange vasculature correlate with growth repression induced by a variant of citrus tristeza virus.Frontiers in microbiology · 2023Article
- Article
- Transcriptional and post-transcriptional regulation of RNAi-related gene expression during plant-virus interactions.Stress biology · 2022Review
- Analysis of the RNA-Dependent RNA Polymerase 1 (RDR1) Gene Family in Melon.Plants (Basel, Switzerland) · 2022Article
- Absence of major epigenetic and transcriptomic changes accompanying an interspecific cross between peach and almond.Horticulture research · 2022Article
- Multigene manipulation of photosynthetic carbon metabolism enhances the photosynthetic capacity and biomass yield of cucumber under low-COFrontiers in plant science · 2022Article
- Unravelling cucumber resistance to several viruses via genome-wide association studies highlighted resistance hotspots and new QTLs.Horticulture research · 2022Article
- Cucumber RDR1s and cucumber mosaic virus suppressor protein 2b association directs host defence in cucumber plants.Molecular plant pathology · 2021Article
- RNA-dependent RNA polymerase 1 delays the accumulation of viroids in infected plants.Molecular plant pathology · 2021Article
- New early phenotypic markers for cucumber green mottle mosaic virus disease in cucumbers exposed to fluctuating extreme temperatures.Scientific reports · 2021Article
- RNA-Seq Transcriptome Analysis Provides Candidate Genes for Resistance toFrontiers in plant science · 2021Article
- Genomic-Assisted Marker Development Suitable forFrontiers in plant science · 2021Article
- Identification of transcription factor binding sites on promoter ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2019Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA-dependent RNA polymerase 1 (RDR1) plays a crucial role in plant defence against viruses. In this study, it was observed that cucumber, Cucumis sativus, uniquely encodes a small gene family of four RDR1 genes. The cucumber RDR1 genes (CsRDR1a, CsRDR1b and duplicated CsRDR1c1/c2) shared 55%-60% homology in their encoded amino acid sequences. In healthy cucumber plants, RDR1a and RDR1b transcripts were expressed at higher levels than transcripts of RDR1c1/c2, which were barely detectable. The expression of all four CsRDR1 genes was induced by virus infection, after which the expression level of CsRDR1b increased 10-20-fold in several virus-resistant cucumber cultivars and in a broad virus-resistant transgenic cucumber line expressing a high level of transgene small RNAs, all without alteration in salicylic acid (SA) levels. By comparison, CsRDR1c1/c2 genes were highly induced (25-1300-fold) in susceptible cucumber cultivars infected with RNA or DNA viruses. Inhibition of RDR1c1/c2 expression led to increased virus accumulation. Ectopic application of SA induced the expression of cucumber RDR1a, RDR1b and RDRc1/c2 genes. A constitutive high level of RDR1b gene expression independent of SA was found to be associated with broad virus resistance. These findings show that multiple RDR1 genes are involved in virus resistance in cucumber and are regulated in a coordinated fashion with different expression profiles.
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