ArticleChemSusChem2017
Enzymatic Specific Production and Chemical Functionalization of Phenylpropanone Platform Monomers from Lignin.
Article in ChemSusChem, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 56 citations in OpenAlex.
- Efficient Lignin Dissolution and Enzymatic Depolymerization in Ethylene Glycol-Based Deep Eutectic Solvent Mixtures: Integrated Experimental and Molecular Dynamics Study.The journal of physical chemistry. B · 2026Article
- The etherase system of Novosphingobium sp. MBES04 functions as a sensor of lignin fragments through phenylpropanone production to induce specific transcriptional responses.Environmental microbiology reports · 2024Article
- Enzymatic Preparation and Characterization of Spherical Microparticles Composed of Artificial Lignin and TEMPO-Oxidized Cellulose Nanofiber.Nanomaterials (Basel, Switzerland) · 2021Article
- Roles of two glutathione S-transferases in the final step of the β-aryl ether cleavage pathway in Sphingobium sp. strain SYK-6.Scientific reports · 2020Article
- Database Mining for Novel Bacterial β-Etherases, Glutathione-Dependent Lignin-Degrading Enzymes.Applied and environmental microbiology · 2020Article
- A heterodimeric glutathioneThe Journal of biological chemistry · 2019Article
- Structure-dependent antiviral activity of catechol derivatives in pyroligneous acid against the encephalomycarditis virus.RSC advances · 2018Article
- Robust Surface Plasmon Resonance Chips for Repetitive and Accurate Analysis of Lignin-Peptide Interactions.ACS omega · 2018Article
- Bacterial Catabolism of β-Hydroxypropiovanillone and β-Hydroxypropiosyringone Produced in the Reductive Cleavage of Arylglycerol-β-Aryl Ether in Lignin.Applied and environmental microbiology · 2018Article
- Article
- Expanding the biomass derived chemical space.Chemical science · 2017Article
- Enzymatic Specific Production and Chemical Functionalization of Phenylpropanone Platform Monomers from Lignin.ChemSusChem · 2017Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enzymatic catalysis is an ecofriendly strategy for the production of high-value low-molecular-weight aromatic compounds from lignin. Although well-definable aromatic monomers have been obtained from synthetic lignin-model dimers, enzymatic-selective synthesis of platform monomers from natural lignin has not been accomplished. In this study, we successfully achieved highly specific synthesis of aromatic monomers with a phenylpropane structure directly from natural lignin using a cascade reaction of β-O-4-cleaving bacterial enzymes in one pot. Guaiacylhydroxylpropanone (GHP) and the GHP/syringylhydroxylpropanone (SHP) mixture are exclusive monomers from lignin isolated from softwood (Cryptomeria japonica) and hardwood (Eucalyptus globulus). The intermediate products in the enzymatic reactions show the capacity to accommodate highly heterologous substrates at the substrate-binding sites of the enzymes. To demonstrate the applicability of GHP as a platform chemical for bio-based industries, we chemically generate value-added GHP derivatives for bio-based polymers. Together with these chemical conversions for the valorization of lignin-derived phenylpropanone monomers, the specific and enzymatic production of the monomers directly from natural lignin is expected to provide a new stream in "white biotechnology" for sustainable biorefineries.
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