ArticleEndocrine2017
Growth hormone deficiency and hypopituitarism in adults after complicated mild traumatic brain injury.
Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- The vasoprotective role of IGF-1 signaling in the cerebral microcirculation: prevention of cerebral microhemorrhages in aging.GeroScience · 2025Review
- Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms.Journal of personalized medicine · 2025Review
- Pituitary dysfunction following mild traumatic brain injury in female athletes.Endocrine connections · 2024Article
- Liver acts as a metabolic gate for the traumatic brain injury pathology: Protective action of thyroid hormone.Biochimica et biophysica acta. Molecular basis of disease · 2023Article
- The association between blast exposure and transdiagnostic health symptoms on systemic inflammation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Growth hormone deficiency testing and treatment following mild traumatic brain injury.Scientific reports · 2021Article
- Prevalence of hypopituitarism and quality of life in survivors of post-traumatic brain injury.Endocrinology, diabetes & metabolism · 2020Article
- Growth Hormone Alters Brain Morphometry, Connectivity, and Behavior in Subjects with Fatigue after Mild Traumatic Brain Injury.Journal of neurotrauma · 2020Article
- Traumatic Brain Injury-Induced Sex-Dependent Changes in Late-Onset Sensory Hypersensitivity and Glutamate Neurotransmission.Frontiers in neurology · 2020Article
- Brain Trauma Disrupts Hepatic Lipid Metabolism: Blame It on Fructose?Molecular nutrition & food research · 2019Article
- Growth Hormone Deficiency Following Traumatic Brain Injury.International journal of molecular sciences · 2019Review
- Making sense of gut feelings in the traumatic brain injury pathogenesis.Neuroscience and biobehavioral reviews · 2019Review
- Review
- A clinical and pathophysiological approach to traumatic brain injury-induced pituitary dysfunction.Pituitary · 2019Review
- Pituitary pathology in traumatic brain injury: a review.Pituitary · 2019Review
- Review
- Evidence of a distinct peripheral inflammatory profile in sport-related concussion.Journal of neuroinflammation · 2019Observational
- Pituitary dysfunction and association with fatigue in stroke and other acute brain injury.Endocrine connections · 2018Review
- A case series of closed head trauma with pituitary stalk disruption resulting in hypopituitarism.International journal of surgery case reports · 2018Article
- Neuroendocrine Abnormalities Following Traumatic Brain Injury: An Important Contributor to Neuropsychiatric Sequelae.Frontiers in endocrinology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeTraumatic brain injury is considered the main cause of hypopituitarism in adults, and GH deficiency appears to be the most frequent pituitary deficit. Most of the available studies have included all degrees of severity of trauma. We aimed to assess pituitary function and GH deficiency in adult patients at different time lengths after complicated mild TBI according to Glasgow Coma Scale. We also aimed to evaluate whether mild TBI patients with GH deficiency had developed alterations in the glycolipid profile.
methodsForty-eight patients (34 men and 14 women) with complicated mild TBI were included in the study. Twenty-three patients were evaluated at 1 year (Group A) and 25 patients at 5 years or longer after the injury (Group B). All patients underwent basal hormonal evaluation for pituitary function. GH deficiency was investigated by the combined test (GH releasing hormone + arginine). The glycolipid profile was also evaluated.
resultsGH deficiency occurred in 8/23 patients (34.7 %) of Group A and in 12/25 patients (48 %) of Group B. In addition, two patients, one in each group, showed evidence of central hypothyroidism. Patients with GH deficiency, especially in Group A, presented a higher frequency of visceral adiposity and adverse metabolic profile as compared to no-GH deficiency patients.
conclusionsPatients examined at 1 year or several years from complicated mild TBI had a similarly high occurrence of isolated GH deficiency, which was associated with visceral adiposity and metabolic alterations. Our findings suggest that patients undergone complicated mild TBI should be evaluated for GH deficiency even after several years from trauma.
Indexed as
Identifiers
27878771What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.