ArticleMolecular neurobiology2017
Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.
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Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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17citing papers in PubMed, 3 pooled it
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genome-wide association study meta-analysis uncovers novel genetic variants associated with olfactory dysfunction.BMC genomic data · 2025Pooled it
- Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants.Nature communications · 2025Pooled it
- Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma.Gastroenterology · 2020Pooled it
- The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults.Scientific reports · 2021Trial
- Molecular Drivers of Mutualistic Association Between Anemone and Anemonefish.Genome biology and evolution · 2026Article
- Bidirectional relationship between olfaction and Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Bidirectional relationship between olfaction and Parkinson's disease.medRxiv : the preprint server for health sciences · 2023Article
- Polygenic risk score for Parkinson's disease and olfaction among middle-aged to older women.Parkinsonism & related disorders · 2023Article
- LOF variants identifying candidate genes of laterality defects patients with congenital heart disease.PLoS genetics · 2022Article
- Does Each Menstrual Cycle Elicit a Distinct Effect on Olfactory and Gustatory Perception?Nutrients · 2021Observational
- Kallmann syndrome in a patient with Weiss-Kruszka syndrome and a de novo deletion in 9q31.2.European journal of endocrinology · 2021Article
- Nuclear Receptor NR5A2 Promotes Neuronal Identity in the Adult Hippocampus.Molecular neurobiology · 2021Article
- Article
- Biallelic mutations of CFAP74 may cause human primary ciliary dyskinesia and MMAF phenotype.Journal of human genetics · 2020Article
- Myosin XVI in the Nervous System.Cells · 2020Review
- High Pesticide Exposure Events and Olfactory Impairment among U.S. Farmers.Environmental health perspectives · 2019Article
- Religious Orders Study and Rush Memory and Aging Project.Journal of Alzheimer's disease : JAD · 2018Review
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Authors and funding
29 authors.
Jing DongEpidemiology Branch, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr. P.O. Box 12233, Mail drop A3-05, Research Triangle Park, NC, 27709, USA. dongj4@mail.nih.gov.
Annah WyssEpidemiology Branch, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr. P.O. Box 12233, Mail drop A3-05, Research Triangle Park, NC, 27709, USA.
Jingyun YangRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
T Ryan PriceLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Aude NicolasLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Michael NallsLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Greg TranahCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Zongli XuEpidemiology Branch, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr. P.O. Box 12233, Mail drop A3-05, Research Triangle Park, NC, 27709, USA.
Claudia SchulteDepartment for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Myriam FornageInstitute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Dmitri ZaykinBiostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Leping LiBiostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Xuemei HuangPennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA.
Stephen KritchevskySticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Yongmei LiuDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Thomas GasserDepartment for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Robert S WilsonRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Philip L De JagerProgram in Translational Neuro Psychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital; Harvard Medical School; Program in Medical and Population Genetics, Broad Institute, Boston, MA, USA.
Andrew B SingletonLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Jayant M PintoSection of Otolaryngology-Head and Neck Surgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Tamara HarrisLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
Thomas H MosleyDivision of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Stephanie LondonEpidemiology Branch, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr. P.O. Box 12233, Mail drop A3-05, Research Triangle Park, NC, 27709, USA.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Honglei ChenEpidemiology Branch, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr. P.O. Box 12233, Mail drop A3-05, Research Triangle Park, NC, 27709, USA.
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MTRANSLATIONAL RESEARCH UNIVERSITY OF CHICAGO: CLINICAL TRIALSUL1RR024999 · NCRR · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2007 to 2011
$25.3MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MAtherosclerosis, Plaque and CVD in CommunitiesU01HL075572 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A · 2004 to 2007
$15.6MARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MCharacterization of Normal Genomic VariabilityZIAAG000932 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW · 2009 to 2024
$11.3MProspective studies on Parkinson's diseaseZIAES101986 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CHEN, HONGLEI · 2009 to 2016
$7.9MIntramural NIH HHS Z01 ES101986NCRR NIH HHS KL2 RR025000NCRR NIH HHS UL1 RR024999NCRR NIH HHS UL1 RR025005NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL070825NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL093029NHLBI NIH HHS U01 HL075572NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS K23 AG036762NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG032098NIA NIH HHS RF1 AG015819NIA NIH HHS RF1 AG036042NIEHS NIH HHS Z01 ES101986NINDS NIH HHS R01 NS087541NINDS NIH HHS U01 NS082151
Abstract
The human sense of smell decreases with age, and a poor sense of smell are among the most important prodromal symptoms of several neurodegenerative diseases. Recent evidence further suggests a racial difference in the sense of smell among U.S. older adults. However, no genome-wide association study (GWAS) on the sense of smell has been conducted in African-Americans (AAs). We performed the first genome-wide meta-analysis of the sense of smell among 1979 AAs and 6582 European-Americans (EAs) from three U.S. aging cohorts. In the AA population, we identified nine novel regions (KLF4-ACTL7B, RAPGEF2-FSTL5, TCF4-LOC100505474, PCDH10, KIAA1751, MYO5B, MIR320B1-CD2, NR5A2-LINC00862, SALL1-C16orf97) that were associated with the sense of smell (P < 5 × 10
Indexed as
AgingGenetic Predisposition to DiseaseAgedBlack or African AmericanFemaleGenome-Wide Association StudyGenotypeHumansKruppel-Like Factor 4MalePolymorphism, Single NucleotideRiskSmellUnited StatesWhite PeopleKruppel-Like Factor 4African-AmericanGWASThe sense of smell
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