Evidence map›Paper›PMID 27878751›Full record

ArticleInternational urology and nephrology2017

Assessment of the relationship between serum paraoxonase activity and epicardial adipose tissue in hemodialysis patients.

Emad Abdallah, Samya El-Shishtawy, Nevine Sherif, Ahmed Ali, Omnia El-Bendary

Abstract read
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Epicardial Adipose Tissue and Renal Disease.Journal of clinical medicine · 2019
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Emad AbdallahDepartment of Nephrology, Theodor Bilharz Research Institute, El-Nile St. Waraq El-Hadar, P.O. Box 30, Imbaba, Giza, 12411, Egypt. drabdallah96@gmail.com.
Samya El-ShishtawyDepartment of Nephrology, Theodor Bilharz Research Institute, El-Nile St. Waraq El-Hadar, P.O. Box 30, Imbaba, Giza, 12411, Egypt.
Nevine SherifDepartment of Nephrology, Theodor Bilharz Research Institute, El-Nile St. Waraq El-Hadar, P.O. Box 30, Imbaba, Giza, 12411, Egypt.
Ahmed AliDepartment of Intensive Care Unit, Theodor Bilharz Research Institute, Cairo, Egypt.
Omnia El-BendaryDepartment of Clinical Chemistry, Theodor Bilharz Research Institute, Cairo, Egypt.
Theodor Bilharz Research Institute · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeParaoxonase-1 (PON-1) is a high-density lipoprotein-associated (HDL) enzyme, which has been shown to reduce susceptibility to low-density lipoprotein (LDL) peroxidation. Epicardial adipose tissue (EAT) is a marker of atherosclerosis. The aim of this study was to determine the relationship between PON-1 activity and EAT in hemodialysis (HD) patients.

methodsThis is a cross-sectional study conducted on 72 (43 males) HD patients with end-stage renal disease. Serum levels for lipid profiles, C-reactive protein, calcium, phosphate, and parathyroid hormone were measured. PON-1 activity was also measured and compared to the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol. Echocardiography was used to measure EAT thickness (EATT). The correlation between PON-1 and EATT was assessed, while independent predictors of EATT in HD patients were similarly assessed using multivariate regression analysis.

resultsThere was a significant low mean value of PON-1 activity in HD patients compared with the control group (82.1 ± 31.6 vs. 164.3 ± 61.5 U/l, p = 0.0001) and significant high mean value of EATT in HD patients, compared with controls (6.2 ± 1.7 vs. 3.9 ± 1.1 mm, p = 0.0001). In addition, there was a significant negative correlation between PON-1 activity and EATT (r = -0.484, p = 0.0001) and a significant positive correlation between PON-1 activity and HDL-C (r = 0.417, p = 0.0003). PON-1, total cholesterol, triglycerides, LDL, HDL, age, and body mass index were found to be independent predictors of EATT.

conclusionOur study demonstrated that PON-1 activity was significantly lower in HD patients compared with healthy controls and that PON-1 activity was inversely correlated with EATT in this population.

Indexed as

Kidney Failure, ChronicAdipose TissueAdultAryldialkylphosphataseBiomarkersBody Mass IndexCross-Sectional StudiesEchocardiographyEgyptFemaleHumansLipoproteins, LDLMaleMiddle AgedNitrophenolsPericardium4-nitrophenolAryldialkylphosphataseBiomarkersLipoproteins, LDLNitrophenolsEpicardial adipose tissueHemodialysisParaoxonase-1 activity

Identifiers

PMID27878751
OpenAlexW2552336613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.