ArticleEuropean radiology2017
Altered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Working Memory Impairment Induced by Chemotherapy-A Narrative Review.Brain sciences · 2026Review
- Disrupted neurovascular coupling in patients with lung cancer after chemotherapy.Quantitative imaging in medicine and surgery · 2025Article
- Cognitive impairment and brain atrophy in patients with newly diagnosed aggressive lymphoma undergoing standard chemotherapy: a normative analysis.Frontiers in neurology · 2025Article
- Altered regional homogeneity in patients with ovarian cancer treated with chemotherapy: a resting state fMRI study.Brain imaging and behavior · 2022Article
- Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events.Archives of toxicology · 2022Review
- Functional changes of the prefrontal cortex, insula, caudate and associated cognitive impairment (chemobrain) in NSCLC patients receiving different chemotherapy regimen.Frontiers in oncology · 2022Article
- Chemotherapy-induced functional brain abnormality in colorectal cancer patients: a resting-state functional magnetic resonance imaging study.Frontiers in oncology · 2022Article
- Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Comparing the Impact of Laparoscopic Sleeve Gastrectomy and Gastric Cancer Surgery on Resting-State Brain Activity and Functional Connectivity.Frontiers in neuroscience · 2020Article
- Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors.Annals of oncology : official journal of the European Society for Medical Oncology · 2019Review
- Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study.Breast cancer research and treatment · 2019Article
- Altered Spontaneous Brain Activity in Patients With Idiopathic Trigeminal Neuralgia: A Resting-state Functional MRI Study.The Clinical journal of pain · 2018Article
- Altered intrinsic local activity and cognitive dysfunction in HIV patients: A resting-state fMRI study.PloS one · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx).
methodsPatients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test. Correlation analysis was also performed between rsfMRI values (i.e., ReHo, ALFF, and fALFF) and neuropsychological test results.
resultsPatients showed poor performance in verbal memory and executive function and decreased rsfMRI values in the frontal areas even before CTx and showed decreased attention/working memory and executive function after CTx compared to the control subjects. In direct comparison of values before and after CTx, there were no significant differences in neuropsychological test scores, but decreased rsfMRI values were observed at the frontal lobes and right cerebellar region. Among rsfMRI values, lower ALFF in the left inferior frontal gyrus was significantly associated with poor performance of the executive function test.
conclusionsWe observed decreased attention/working memory and executive function that corresponded to the decline of frontal region activation in gastric cancer patients who underwent CTx. KEY POINTS: • Intrinsic brain activity of gastric cancer patients after chemotherapy was described. • Brain activity and neuropsychological test results were correlated. • Working memory and executive function decreased after chemotherapy. • Decreased cognitive function corresponded to decreased activation of the frontal region.
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