ReviewCurrent allergy and asthma reports2016
Interactions of GST Polymorphisms in Air Pollution Exposure and Respiratory Diseases and Allergies.
Review in Current allergy and asthma reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review.Current allergy and asthma reports · 2018Pooled it
- The Role of Air Pollution Exposure andAntioxidants (Basel, Switzerland) · 2025Article
- Genetic susceptibility to airway inflammation and exposure to short-term outdoor air pollution.Environmental health : a global access science source · 2023Article
- Air pollution associated acute respiratory inflammation and modification by GSTM1 and GSTT1 gene polymorphisms: a panel study of healthy undergraduates.Environmental health : a global access science source · 2023Article
- The Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes.Journal of personalized medicine · 2021Article
- Association of GSTM1 and GSTT1 gene polymorphisms with COVID-19 susceptibility and its outcome.Journal of medical virology · 2021Article
- Glutathione S-Transferase Gene Associations and Gene-Environment Interactions for Asthma.Current allergy and asthma reports · 2021Review
- Role ofBiomedical reports · 2021Article
- Expression of xenobiotic metabolising enzymes in lungs of horses with or without histological evidence of lower airway inflammation.Veterinary medicine and science · 2021Article
- Interactions between environmental pollutants and genetic susceptibility in asthma risk.Current opinion in immunology · 2019Review
- Pathway analysis of a genome-wide gene by air pollution interaction study in asthmatic children.Journal of exposure science & environmental epidemiology · 2019Article
- Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients.The Journal of allergy and clinical immunology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe purpose of this review is to summarize the evidence from recently published original studies investigating how glutathione S-transferase (GST) gene polymorphisms modify the impact of air pollution on asthma, allergic diseases, and lung function. RECENT
findingsCurrent studies in epidemiological and controlled human experiments found evidence to suggest that GSTs modify the impact of air pollution exposure on respiratory diseases and allergies. Of the nine articles included in this review, all except one identified at least one significant interaction with at least one of glutathione S-transferase pi 1 (GSTP1), glutathione S-transferase mu 1 (GSTM1), or glutathione S-transferase theta 1 (GSTT1) genes and air pollution exposure. The findings of these studies, however, are markedly different. This difference can be partially explained by regional variation in the exposure levels and oxidative potential of different pollutants and by other interactions involving a number of unaccounted environment exposures and multiple genes. Although there is evidence of an interaction between GST genes and air pollution exposure for the risk of respiratory disease and allergies, results are not concordant. Further investigations are needed to explore the reasons behind the discordancy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.