Evidence map›Paper›PMID 27878476›Full record

ReviewDrugs2016

Management of Post-Liver Transplant Recurrence of Hepatitis C.

Justin Taylor, Paula Cox-North, Charles S Landis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Justin TaylorDivision of Gastroenterology and Hepatology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195-6424, USA.ORCID http://orcid.org/0000-0002-1074-7760
Paula Cox-NorthDivision of Gastroenterology and Hepatology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195-6424, USA.
Charles S LandisDivision of Gastroenterology and Hepatology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195-6424, USA. clandis@medicine.washington.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cirrhosis due to chronic hepatitis C (HCV) is the leading indication for liver transplantation in North America and Europe. HCV re-infection post-transplant is nearly universal and if left untreated negatively affects patient and graft survival. Until recently, treatment options for HCV were limited to interferon (IFN)-based therapies which had low sustained viral response (SVR) rates and were poorly tolerated in the post-transplant setting. In the last 3 years, the promise of the directly acting antivirals (DAAs) for the treatment of HCV has been fulfilled with high sustained viral response (SVR) rates and a low side effect profile demonstrated in both registration trials and real-world studies. This innovation has allowed post-liver transplant patients with HCV recurrence access to interferon-free therapies with extraordinary efficacy, safety, tolerability, and fewer drug-drug interactions.

Indexed as

Antiviral AgentsDisease ManagementDrug InteractionsHepacivirusHepatitis CHumansInterferonsLiver CirrhosisLiver TransplantationRecurrenceAntiviral AgentsInterferons

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.