Evidence map›Paper›PMID 27878470›Full record

ReviewHandbook of experimental pharmacology2017

β

Charlotte K Billington, Raymond B Penn, Ian P Hall

Abstract readReview
In one paragraph

Review in Handbook of experimental pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 2 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 2 syntheses or guidelines pooled it, 207 citations in OpenAlex.

  1. Pooled it
  2. Romanian clinical guideline for diagnosis and treatment of COPD.The Journal of international medical research · 2020
    Guideline
  3. Article
  4. Agonist-specific conformational dynamics at the βBritish journal of pharmacology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Nanotechnology-Based Therapeutics for Airway Inflammatory Diseases.Clinical reviews in allergy & immunology · 2025
    Review
  17. TBrain, behavior, and immunity · 2025
    Article
  18. Review
  19. Observational
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Charlotte K BillingtonDivision of Respiratory Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.
Raymond B PennDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Lung Center, Thomas Jefferson University, Philadelphia, PA, USA.
Ian P HallDivision of Respiratory Medicine, University of Nottingham, Nottingham, NG7 2RD, UK. Ian.hall@nottingham.ac.uk.
University of Nottingham · GBThomas Jefferson University · US

Funding

Project 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LIGGETT, STEPHEN B · 2013 to 2023
$23.9M
G Protein-Coupled Receptor Signaling in Airway Smooth MuR01HL058506 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAYMOND B. PENN · 2001 to 2026
$9.3M
Optimizing Beta-Adrenoceptor Signaling Bias in AsthmaR01AI110007 · NIAID · DUKE UNIVERSITY · PI BOND, RICHARD AGUSTIN, PENN, RAYMOND B. · 2014 to 2018
$3.2M
Regulation of cysteinyl leukotriene type I receptorR01AI059755 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PENN, RAYMOND B. · 2004 to 2007
$1.3M
BETA ADRENERGIC RECEPTOR REGULATION IN HUMAN AIRWAY MUSCR29HL058506 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI PENN, RAYMOND B. · 1997 to 2000
$113k
Medical Research Council G0701390NHLBI NIH HHS P01 HL114471NHLBI NIH HHS R01 HL058506NHLBI NIH HHS R29 HL058506NIAID NIH HHS R01 AI059755NIAID NIH HHS R01 AI110007
6 · The paper itself

Abstract

History suggests β agonists, the cognate ligand of the β

Indexed as

Adrenergic beta-2 Receptor AgonistsAnimalsAsthmaBronchodilator AgentsHumansPharmacogeneticsPolymorphism, Single NucleotidePulmonary Disease, Chronic ObstructiveAdrenergic beta-2 Receptor AgonistsBronchodilator AgentsAirway smooth muscleAsthmaCyclic AMPIsoprenalineβ adrenoceptorβ agonists

Identifiers

PMID27878470
PMCPMC5480238
OpenAlexW2779096619

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.