ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2017
The role of the atrial electromechanical delay in predicting atrial fibrillation in beta-thalassemia major patients.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Electrocardiographic Predictors of Atrial Fibrillation.Medical sciences (Basel, Switzerland) · 2023Pooled it
- Assessing Cardiac Mechanical Dysfunction in Transfusion-Dependent β-Thalassemia With History of Atrial Fibrillation: The Role of Speckle Tracking Echocardiography.Echocardiography (Mount Kisco, N.Y.) · 2026Observational
- Thalassemia-Associated mixed hypogonadism (TAMH): unraveling a unique endocrine pattern and its impact on cardiovascular risk.Endocrine · 2025Observational
- Case-control study on atrial electromechanical coupling time in patients with new-onset postoperative atrial fibrillation.Scientific reports · 2025Article
- Association between epicardial adipose tissue and transfusion-dependent β-thalassemia.The international journal of cardiovascular imaging · 2025Observational
- Cardiac injury caused by iron overload in thalassemia.Frontiers in pediatrics · 2025Review
- Increased inter-atrial and intra-atrial conduction times in pediatric patients with non-alcoholic fatty liver disease.European journal of pediatrics · 2024Article
- Echocardiographic Features of Cardiac Involvement in Myotonic Dystrophy 1: Prevalence and Prognostic Value.Journal of clinical medicine · 2023Review
- Evaluation of electrocardiography, echocardiography and cardiac T2* for cardiac complications in beta thalassemia major.The international journal of cardiovascular imaging · 2022Article
- Atrial Fibrillation in β-Thalassemia: Overview of Mechanism, Significance and Clinical Management.Biology · 2022Review
- Early Detection of Iron Overload Cardiomyopathy in Transfusion Dependent Thalassemia Patients in Sulaimaniyah City, Iraq.Therapeutics and clinical risk management · 2022Article
- Evolution of electrocardiographic abnormalities and arrhythmias in adult patients with beta-thalassemia major during a short-term follow-up.American journal of cardiovascular disease · 2021Article
- Twelve-lead and signal-averaged electrocardiographic parameters among beta-thalassemia major patients.Journal of arrhythmia · 2020Article
- Atrial fibrillation in β-thalassemia patients with a focus on the role of iron-overload and oxidative stress: A review.Journal of cellular physiology · 2019Review
- Evaluation of Atrial Electromechanical Delay in Children with Obesity.Medicina (Kaunas, Lithuania) · 2019Article
- Arrhythmias and Sudden Cardiac Death in Beta-Thalassemia Major Patients: Noninvasive Diagnostic Tools and Early Markers.Cardiology research and practice · 2019Review
- Evaluation of Atrial Electromechanical Delay to Predict Atrial Fibrillation in Hemodialysis Patients.Medicina (Kaunas, Lithuania) · 2018Article
- Usefulness of the external loop recorder in a patient with Myotonic Dystrophy type 1 and recurrent episodes of palpitations: evaluation of the follow-up from diagnosis to 6 month-post-cardiac interventional treatment.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2018Article
- Bachmann bundle pacing reduces atrial electromechanical delay in type 1 myotonic dystrophy patients.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2018Observational
- Complete resolution of left atrial appendage thrombosis with oral dabigatran etexilate in a patient with Myotonic Dystrophy type 1 and atrial fibrillation.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParoxysmal atrial tachyarrhythmias frequently occur in beta-thalassemia major (β-TM) patients. The aim of the current study was to evaluate the atrial electromechanical delay (AEMD) in a large β-TM population with normal cardiac function and its relationship to atrial fibrillation (AF) onset.
methodsEighty β-TM patients (44 men, 36 women), with a mean age of 36.2 ± 11.1 years, and 80 healthy subjects used as controls, matched for age and gender, were studied for the occurrence of AF during a 5-year follow-up, through 30-day external loop recorder (ELR) monitoring performed every 6 months. Intra-AEMD and inter-AEMD of both atria were measured through tissue Doppler echocardiography. P-wave dispersion (PD) was carefully measured using 12-lead electrocardiogram (ECG).
resultsCompared to the healthy control group, the β-TM patients showed a statistically significant increase in inter-AEMD, intra-left AEMD, maximum P-wave duration, and PD. Dividing the β-TM group into two subgroups (patients with or without AF), the inter-AEMD, intra-left AEMD, maximum P-wave duration, and PD were significantly higher in the subgroup with AF compared to the subgroup without AF. There were significant good correlations of intra-left AEMD and inter-AEMD with PD. A cut-off value of 40.1 ms for intra-left AEMD had a sensitivity of 76.2% and a specificity of 97.5% in identifying β-TM patients with AF risk. A cut-off value of 44.8 ms for inter-AEMD had a sensitivity of 81.2% and a specificity of 98.7% in identifying this category of patients.
conclusionsOur results showed that the echocardiographic atrial electromechanical delay indices (intra-left and inter-AEMD) and the PD were significantly increased in β-TM subjects with normal cardiac function. PD and AEMD represent non-invasive, inexpensive, useful, and simple parameters to assess the AF risk in β-TM patients.
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