ArticleEuropean archives of psychiatry and clinical neuroscience2018
Amygdala structure and aggressiveness in borderline personality disorder.
Article in European archives of psychiatry and clinical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Hemispheric asymmetries in borderline personality disorder: a systematic review.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Gender differences in borderline personality disorder: a narrative review.Frontiers in psychiatry · 2024Review
- Regional superficial amygdala resting-state functional connectivity in adults infers childhood maltreatment severity.Psychoradiology · 2023Article
- Article
- Understanding Brain Mechanisms of Reactive Aggression.Current psychiatry reports · 2020Review
- Distinct Functional Connectivity Signatures of Impaired Social Cognition in Multiple Sclerosis.Frontiers in neurology · 2020Article
- Subcortical Shape Abnormalities in Bulimia Nervosa.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Correlates of Aggression in Personality Disorders: an Update.Current psychiatry reports · 2018Review
- Aggression in Women: Behavior, Brain and Hormones.Frontiers in behavioral neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Aggressiveness is considered an important clinical feature of borderline personality disorder (BPD) and has been associated with alterations of the amygdala. However, studies that analyzed the exact location of amygdala alterations associated with aggressiveness in BPD or that systematically compared female and male BPD patients are missing. In the current study, we therefore investigated a sex-mixed sample of BPD patients and healthy volunteers and applied an automated segmentation method that allows the study of both, alterations of amygdala volume and localized amygdala shape. Volumetric results revealed no difference in amygdala volume between BPD patients and healthy volunteers, but a trend for a positive association between volume of the right amygdala and aggressiveness in male BPD patients. Analyses of amygdala shape showed a trend for a group by sex interaction effect in the left laterobasal amygdala, without a difference in subgroup analyses. Finally, regions of the left superficial and laterobasal amygdala of male BPD patients were positively associated with aggressiveness. In sum, our results emphasize the need to consider sex-specific effects and demonstrate a link between male BPD patients' aggressiveness and amygdala regions that are particularly related to social information processing and associative emotional learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.