ArticleRevista latino-americana de enfermagem2016
Potential drug interactions in patients given antiretroviral therapy.
Article in Revista latino-americana de enfermagem, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Prevalence of potentially inappropriate medications in people living with HIV: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- An HIV-Infected Patient Developed Immune Reconstitution Inflammatory Syndrome Immune Reconstitution Inflammatory Syndrome After Antiretroviral Therapy and Was Diagnosed with Primary Immune Thrombocytopenia, Latent Autoimmune Diabetes in Adults, and Hashimoto Thyroiditis: A Case Report and Review of the Literature.Infection and drug resistance · 2025Article
- Potential drug interactions in adults living in the Brazilian Amazon: A population-based case-control study, 2019.Exploratory research in clinical and social pharmacy · 2021Article
- Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases.Scientific reports · 2021Article
- Assessment of factors associated with potential drug-drug interactions in patients with tuberculosis and HIV/AIDS.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
- Potential drug-drug interactions among pneumonia patients: do these matter in clinical perspectives?BMC pharmacology & toxicology · 2019Article
- Potential Drug-Drug Interactions in Patients With Urinary Tract Infections: A Contributing Factor in Patient and Medication Safety.Frontiers in pharmacology · 2019Article
- Adverse reactions associated with first-line regimens in patient initiating antiretroviral therapy.European journal of clinical pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: to investigate potential drug-drug interactions (PDDI) in patients with HIV infection on antiretroviral therapy. Methods: a cross-sectional study was conducted on 161 adults with HIV infection. Clinical, socio demographic, and antiretroviral treatment data were collected. To analyze the potential drug interactions, we used the software Micromedex(r). Statistical analysis was performed by binary logistic regression, with a p-value of ≤0.05 considered statistically significant. Results: of the participants, 52.2% were exposed to potential drug-drug interactions. In total, there were 218 potential drug-drug interactions, of which 79.8% occurred between drugs used for antiretroviral therapy. There was an association between the use of five or more medications and potential drug-drug interactions (p = 0.000) and between the time period of antiretroviral therapy being over six years and potential drug-drug interactions (p < 0.00). The clinical impact was prevalent sedation and cardiotoxicity. Conclusions: the PDDI identified in this study of moderate and higher severity are events that not only affect the therapeutic response leading to toxicity in the central nervous and cardiovascular systems, but also can interfere in tests used for detection of HIV resistance to antiretroviral drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.