Control of the heart rate of rat embryos during the organogenic period.

Helen E Ritchie, Carolina Ragnerstam, Elin Gustafsson, Johanna M Jonsson, William S Webster

Open access · diamondAbstract read

In one paragraph

Article in Hypoxia (Auckland, N.Z.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Chicken embryos can maintain heart rate during hypoxia on day 4 of incubation.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Helen E RitchieDiscipline of Biomedical Science, Sydney Medical School, University of Sydney, Lidcombe.

Carolina RagnerstamDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

Elin GustafssonDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

Johanna M JonssonDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

William S WebsterDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to gain insight into whether the first trimester embryo could control its own heart rate (HR) in response to hypoxia. The gestational day 13 rat embryo is a good model for the human embryo at 5-6 weeks gestation, as the heart is comparable in development and, like the human embryo, has no functional autonomic nerve supply at this stage. Utilizing a whole-embryo culture technique, we examined the effects of different pharmacological agents on HR under normoxic (95% oxygen) and hypoxic (20% oxygen) conditions. Oxygen concentrations ≤60% caused a concentration-dependent decrease in HR from normal levels of ~210 bpm. An adenosine agonist, AMP-activated protein kinase (AMPK) activator and K

Indexed as

ATPbradycardiaembryoembryonic heart ratehypoxiain vitro

Identifiers

PMID27878135

DOI10.2147/HP.S115050

PMCPMC5108485

OpenAlexW2552211949

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.