Evidence map›Paper›PMID 27878102›Full record

ArticleWorld journal of virology2016

Antiretroviral naive and treated patients: Discrepancies of B cell subsets during the natural course of human immunodeficiency virus type 1 infection.

Olga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Apostolia Margariti, Adamantini Georgiou, Dimitrios Bougiouklis, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Olga TsachouridouOlga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Adamantini Georgiou, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis, 1 Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Lemonia SkouraOlga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Adamantini Georgiou, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis, 1 Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Pantelis ZebekakisOlga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Adamantini Georgiou, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis, 1 Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Apostolia MargaritiOlga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Adamantini Georgiou, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis, 1 Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Adamantini GeorgiouOlga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Adamantini Georgiou, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis, 1 Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Dimitrios BougiouklisOlga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Adamantini Georgiou, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis, 1 Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Dimitrios PilalasOlga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Adamantini Georgiou, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis, 1 Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Antonios GalanosOlga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Adamantini Georgiou, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis, 1 Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Michael DaniilidisOlga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Adamantini Georgiou, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis, 1 Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Symeon MetallidisOlga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Adamantini Georgiou, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis, 1 Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Aristotle University of Thessaloniki · GROffice of Infectious Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate alterations of memory B cell subpopulations during a 48-wk period in human immunodeficiency virus type 1 (HIV-1) patients.

methodsForty-one antiretroviral naïve and 41 treated HIV-1 patients matched for age and duration of HIV infection were recruited. All clinical, epidemiological and laboratory data were recorded or measured. The different B cell subsets were characterized according to their surface markers: Total B cells (CD19

resultsMean counts of BMCs were higher in treated patients. There was a marginal upward trend of IgM memory B cell proportions which differed significantly in the treated group (overall trend,

conclusionHIV disrupts memory B cell subpopulations leading to impaired immunologic memory over time. BMC, RM, EM and ITS BMC were higher in patients under HAART. Activated BMCs (AM) were higher in patients without HAART. Viremia correlated with AM and RM. Significant depletion was recorded in EM B cells irrespectively of HAART intake. Perturbations in BMC-populations are not fully restored by antiretrovirals.

Indexed as

B cell subpopulationsHighly active antiretroviral therapyHuman immunodeficiency virus infectionMemory cellsTime-trend

Identifiers

PMID27878102
PMCPMC5105048
OpenAlexW2553987591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.