Evidence map›Paper›PMID 27878101›Full record

ReviewWorld journal of virology2016

Regulation of Wnt/β-catenin signaling by herpesviruses.

Kevin J Zwezdaryk, Joseph A Combs, Cindy A Morris, Deborah E Sullivan

Open access · diamondAbstract readReview
In one paragraph

Review in World journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  5. Review
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  9. Viruses in colorectal cancer.Molecular oncology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kevin J ZwezdarykKevin J Zwezdaryk, Joseph A Combs, Cindy A Morris, Deborah E Sullivan, Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, United States.
Joseph A CombsKevin J Zwezdaryk, Joseph A Combs, Cindy A Morris, Deborah E Sullivan, Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, United States.
Cindy A MorrisKevin J Zwezdaryk, Joseph A Combs, Cindy A Morris, Deborah E Sullivan, Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, United States.
Deborah E SullivanKevin J Zwezdaryk, Joseph A Combs, Cindy A Morris, Deborah E Sullivan, Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, United States.
Tulane University · USCreative Research Enterprises (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Wnt/β-catenin signaling pathway is instrumental in successful differentiation and proliferation of mammalian cells. It is therefore not surprising that the herpesvirus family has developed mechanisms to interact with and manipulate this pathway. Successful coexistence with the host requires that herpesviruses establish a lifelong infection that includes periods of latency and reactivation or persistence. Many herpesviruses establish latency in progenitor cells and viral reactivation is linked to host-cell proliferation and differentiation status. Importantly, Wnt/β-catenin is tightly connected to stem/progenitor cell maintenance and differentiation. Numerous studies have linked Wnt/β-catenin signaling to a variety of cancers, emphasizing the importance of Wnt/β-catenin pathways in development, tissue homeostasis and disease. This review details how the alpha-, beta-, and gammaherpesviruses interact and manipulate the Wnt/β-catenin pathway to promote a virus-centric agenda.

Indexed as

AxinCytomegalovirusEpstein-Barr virusGlycogen synthase kinase-3Herpes simplex virus-1HerpesvirusKaposi’s sarcoma-associated herpesvirusVaricella zoster virusWnt/β-catenin

Identifiers

PMID27878101
PMCPMC5105047
OpenAlexW2549899421

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.