Evidence map›Paper›PMID 27877894›Full record

ArticleScience and technology of advanced materials2016

Cooperative enhancement of deoxyribozyme activity by chemical modification and added cationic copolymer.

Ken Saito, Naohiko Shimada, Atushi Maruyama

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science and technology of advanced materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Chemically Evolved XNAzyme Platforms for Effective In Vivo Gene Regulation.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. The Programmable Catalytic Core of 8-17 DNAzymes.Molecules (Basel, Switzerland) · 2024
    Article
  3. Article
  4. [Antiviral effect of hepatitis B virus S gene-specific anti-gene locked nucleic acid in transgenic mice].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ken SaitoDepartment of Life Science and Technology, Tokyo Institute of Technology , Yokohama , Japan.
Naohiko ShimadaDepartment of Life Science and Technology, Tokyo Institute of Technology , Yokohama , Japan.
Atushi MaruyamaDepartment of Life Science and Technology, Tokyo Institute of Technology , Yokohama , Japan.
Tokyo Institute of Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deoxyribozymes (DNAzymes) having RNA-cleaving activity have widely been explored as tools for therapeutic and diagnostic purposes. Both the chemical cleaving step and the turnover step should be improved for enhancing overall activity of DNAzymes. We have shown that cationic copolymer enhanced DNAzyme activity by increasing turnover efficacy. In this paper, effectｓ of the copolymer on DNAzymes modified with locked nucleic acids (LNA) or 2'-

Indexed as

101 Self-assembly / Self-organized materials211 Scaffold/Tissue engineering/Drug delivery2’ O-Methyl RNA30 Bio-inspired and biomedical materialsCationic copolymerDeoxyribozymeLocked Nucleic AcidTurnover reaction

Identifiers

PMID27877894
PMCPMC5102035
OpenAlexW2496039254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.