Evidence map›Paper›PMID 27877883›Full record

ArticleScience and technology of advanced materials2016

Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells.

Kazuhiko Ishihara, Weixin Chen, Yihua Liu, Yuriko Tsukamoto, Yuuki Inoue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science and technology of advanced materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Biomimetic polymers with phosphorylcholine groups as biomaterials for medical devices.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Self-assembly as a key player for materials nanoarchitectonics.Science and technology of advanced materials · 2019
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kazuhiko IshiharaDepartment of Materials Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan; Department of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan.
Weixin ChenDepartment of Materials Engineering, School of Engineering, The University of Tokyo , Tokyo , Japan.
Yihua LiuDepartment of Bioengineering, School of Engineering, The University of Tokyo , Tokyo , Japan.
Yuriko TsukamotoDepartment of Materials Engineering, School of Engineering, The University of Tokyo , Tokyo , Japan.
Yuuki InoueDepartment of Materials Engineering, School of Engineering, The University of Tokyo , Tokyo , Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multifunctional polymeric nanoparticles are materials with great potential for a wide range of biomedical applications. For progression in this area of research, unfavorable interactions of these nanoparticles with proteins and cells must be avoided in biological environments, for example, through treatment of the nanoparticle surfaces. Construction of an artificial cell membrane structure based on polymers bearing the zwitterionic phosphorylcholine group can prevent biological reactions at the surface effectively. In addition, certain bioactive molecules can be immobilized on the surface of the polymer to generate enough affinity to capture target biomolecules. Furthermore, entrapment of inorganic nanoparticles inside polymeric matrices enhances the nanoparticle functionality significantly. This review summarizes the preparation and characterization of cytocompatible and multifunctional polymeric nanoparticles; it analyzes the efficiency of their fluorescence function, the nature of the artificial cell membrane structure, and their performance as in-cell devices; and finally, it evaluates both their chemical reactivity and effects in cells.

Indexed as

30 Bio-inspired and biomedical materials600 Biomaterials, Nano materialscytocompatibilityfluorescence propertyin-cell deviceNanomedicine molecular sciencesurface modificationzwitterionic polymer

Identifiers

PMID27877883
PMCPMC5111563

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.