ArticleScience and technology of advanced materials2012
PLLA-collagen and PLLA-gelatin hybrid scaffolds with funnel-like porous structure for skin tissue engineering.
Article in Science and technology of advanced materials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Conditions to Consider When Choosing Fillers.Journal of cosmetic dermatology · 2025Pooled it
- Early Biocompatibility of Brown Macroalgal Scaffolds in a Splinted Full-Thickness Rodent Wound Model: A Pilot Study.Journal of functional biomaterials · 2026Article
- Recent Advances in Diversified Materials for Spinal Cord Injury Repair and Regeneration.Gels (Basel, Switzerland) · 2026Review
- Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness.International journal of molecular sciences · 2024Review
- Effect of Gelatin Content on Degradation Behavior of PLLA/Gelatin Hybrid Membranes.Tissue engineering and regenerative medicine · 2024Article
- Gelatin Enhances the Wet Mechanical Properties of Poly(D,L-Lactic Acid) Membranes.International journal of molecular sciences · 2024Article
- High-resolution 3-D scanning electron microscopy (SEM) images of DOTSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- What are filling (volumizing) threads?Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Review
- Poly-l-lactic acid microspheres delay aging of epidermal stem cells in rat skin.Frontiers in immunology · 2024Article
- Electrospun Poly(L-Lactic Acid)/Gelatin Hybrid Polymer as a Barrier to Periodontal Tissue Regeneration.Polymers · 2023Article
- Technological advances in ocular trabecular meshwork in vitro models for glaucoma research.Biotechnology and bioengineering · 2022Review
- Article
- Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications.Polymers · 2022Review
- 3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity.Molecules (Basel, Switzerland) · 2020Article
- A salt-based method to adapt stiffness and biodegradability of porous collagen scaffolds.RSC advances · 2019Article
- Fabrication of Three-Dimensional Scaffolds Based on Nano-biomimetic Collagen Hybrid Constructs for Skin Tissue Engineering.ACS omega · 2018Article
- Biomaterials for Skin Substitutes.Advanced healthcare materials · 2018Review
- Synthesis and characterization of PLGA/collagen composite scaffolds as skin substitute produced by electrospinning through two different approaches.Journal of materials science. Materials in medicine · 2017Article
- Methodologies in creating skin substitutes.Cellular and molecular life sciences : CMLS · 2016Review
- Extracellular Matrix-Based Biohybrid Materials for Engineering Compliant, Matrix-Dense Tissues.Advanced healthcare materials · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In skin tissue engineering, a three-dimensional porous scaffold is necessary to support cell adhesion and proliferation and to guide cells moving into the repair area in the wound healing process. Structurally, the porous scaffold should have an open and interconnected porous architecture to facilitate homogenous cell distribution. Moreover, the scaffolds should be mechanically strong to protect deformation during the formation of new skin. In this study, the hybrid scaffolds were prepared by forming funnel-like collagen or gelatin sponge on a woven poly(l-lactic acid) (PLLA) mesh. The hybrid scaffolds combined the advantages of both collagen or gelatin (good cell-interactions) and PLLA mesh (high mechanical strength). The hybrid scaffolds were used to culture dermal fibroblasts for dermal tissue engineering. The funnel-like porous structure promoted homogeneous cell distribution and extracellular matrix production. The PLLA mesh reinforced the scaffold to avoid deformation. Subcutaneous implantation showed that the PLLA-collagen and PLLA-gelatin scaffolds promoted the regeneration of dermal tissue and epidermis and reduced contraction during the formation of new tissue. These results indicate that funnel-like hybrid scaffolds can be used for skin tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.