Evidence map›Paper›PMID 27877245›Full record

ReviewTheranostics2016

Imaging Nanotherapeutics in Inflamed Vasculature by Intravital Microscopy.

Zhenjia Wang

Abstract readReview
In one paragraph

Review in Theranostics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Nanomedicine for Ischemic Stroke.International journal of molecular sciences · 2020
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Textures of the tumour microenvironment.Essays in biochemistry · 2019
    Review
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Zhenjia WangDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, USA.

Funding

Neutrophil-mediated Drug DeliveryR01GM116823 · NIGMS · WASHINGTON STATE UNIVERSITY · PI WANG, ZHENJIA · 2016 to 2020
$1.8M
Caveolar Transport of Therapeutic NanoparticlesK25HL111157 · NHLBI · WASHINGTON STATE UNIVERSITY · PI WANG, ZHENJIA · 2012 to 2016
$621k
NHLBI NIH HHS K25 HL111157NIGMS NIH HHS R01 GM116823
6 · The paper itself

Abstract

Intravital microscopy (IVM) is the application of light microscopy to real time study biology of live animal tissues in intact and physiological conditions with the high spatial and temporal resolution. Advances in imaging systems, genetic animal models and imaging probes, IVM has offered quantitative and dynamic insight into cell biology, immunology, neurobiology and cancer. In this review, we will focus on the targeting of nanotherapeutics to inflamed vasculature. We will introduce the basic concept and principle of IVM and demonstrate that IVM is a powerful tool used to quantitatively determine the molecular mechanisms of interactions between nanotherapeutics and neutrophils or endothelium in living mice. In the future, it is needed to develop new imaging systems and novel imaging contrast agents to better understand molecular mechanisms of tissue processing of nanotherapeutics in vivo.

Indexed as

AnimalsBlood VesselsIntravital MicroscopyMiceMolecular Diagnostic TechniquesNanostructuresOptical ImagingInflammationIntravital Microscopy (IVM)NanoparticlesNeutrophils and Endothelium.

Identifiers

PMID27877245
PMCPMC5118605

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.