ArticleFrontiers in aging neuroscience2016
Changes in Neural Activity Underlying Working Memory after Computerized Cognitive Training in Older Adults.
Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Successful Aging and Enrichment (SAGE): Effects of Environmental Stimulation on Cognitive Health and Neuroplasticity
Computerized Cognitive Training: Characterization of Factors That Predict Cognitive Enhancement in Acquired Brain Injury
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Game a Day Keeps Cognitive Decline Away? A Systematic Review and Meta-Analysis of Commercially-Available Brain Training Programs in Healthy and Cognitively Impaired Older Adults.Neuropsychology review · 2022Pooled it
- A Systematic Review on Predictors of Working Memory Training Responsiveness in Healthy Older Adults: Methodological Challenges and Future Directions.Frontiers in aging neuroscience · 2020Pooled it
- Practice makes perfect, but to what end? Computerised brain training has limited cognitive benefits in healthy ageing.Psychological research · 2025Trial
- A comparison of single-domain and multidomain executive functions cognitive training for enhancing cognition and well-being in older adults.Psychological research · 2026Article
- Executive Function and Transfer Effect Training in Children: A Behavioral and Event-Related Potential Pilot Study.Behavioral sciences (Basel, Switzerland) · 2025Article
- Artificial Cognitive Systems Applied in Executive Function Stimulation and Rehabilitation Programs: A Systematic Review.Arabian journal for science and engineering · 2023Article
- Event-Related Potentials as Markers of Efficacy for Combined Working Memory Training and Transcranial Direct Current Stimulation Regimens: A Proof-of-Concept Study.Frontiers in systems neuroscience · 2022Article
- The effects of working memory training in children revealed by behavioral responses and ERP.Brain and behavior · 2021Article
- Behavioural and ERP Effects of Cognitive and Combined Cognitive and Physical Training on Working Memory and Executive Function in Healthy Older Adults.Advances in cognitive psychology · 2021Article
- Can Working Memory Task-Related EEG Biomarkers Measure Fluid Intelligence and Predict Academic Achievement in Healthy Children?Frontiers in behavioral neuroscience · 2020Article
- Effects of Computerized Updating and Inhibition Training in Older Adults: The ACTOP Three-Arm Randomized Double-Blind Controlled Trial.Frontiers in neurology · 2020Article
- Potential of video games for the promotion of neuroadaptation to multifocal intraocular lenses: a narrative review.International journal of ophthalmology · 2019Review
- Neural and Behavioral Effects of an Adaptive Online Verbal Working Memory Training in Healthy Middle-Aged Adults.Frontiers in aging neuroscience · 2019Article
- Markers of Novelty Processing in Older Adults Are Stable and Reliable.Frontiers in aging neuroscience · 2019Article
- Potential Mechanisms for the Ketamine-Induced Reduction of P3b Amplitudes.Frontiers in behavioral neuroscience · 2018Article
- Open- and Closed-Skill Exercise Interventions Produce Different Neurocognitive Effects on Executive Functions in the Elderly: A 6-Month Randomized, Controlled Trial.Frontiers in aging neuroscience · 2017Article
- Anodal Transcranial Direct Current Stimulation Promotes Frontal Compensatory Mechanisms in Healthy Elderly Subjects.Frontiers in aging neuroscience · 2017Article
- Task-Irrelevant Novel Sounds have Antithetical Effects on Visual Target Processing in Young and Old Adults.Frontiers in aging neuroscience · 2017Article
- Brain Changes Following Executive Control Training in Older Adults.Neurorehabilitation and neural repairArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Computerized cognitive training (CCT) may counter the impact of aging on cognition, but both the efficacy and neurocognitive mechanisms underlying CCT remain controversial. In this study, 35 older individuals were randomly assigned to Cogmed adaptive working memory (WM) CCT or an active control CCT, featuring five weeks of five ∼40 min sessions per week. Before and after the 5-week intervention, event-related potentials were measured while subjects completed a visual n-back task with three levels of demand (0-back, 1-back, 2-back). The anterior P3a served as an index of directing attention and the posterior P3b as an index of categorization/WM updating. We hypothesized that adaptive CCT would be associated with decreased P3 amplitude at low WM demand and increased P3 amplitude at high WM demand. The adaptive CCT group exhibited a training-related increase in the amplitude of the anterior P3a and posterior P3b in response to target stimuli across n-back tasks, while subjects in the active control CCT group demonstrated a post-training decrease in the anterior P3a. Performance did not differ between groups or sessions. Larger overall P3 amplitudes were strongly associated with better task performance. Increased post-CCT P3 amplitude correlated with improved task performance; this relationship was especially robust at high task load. Our findings suggest that adaptive WM training was associated with increased orienting of attention, as indexed by the P3a, and the enhancement of categorization/WM updating processes, as indexed by the P3b. Increased P3 amplitude was linked to improved performance; however. there was no direct association between adaptive training and improved performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.