Evidence map›Paper›PMID 27877110›Full record

ArticleFrontiers in molecular neuroscience2016

Forward Genetic Screen in

Xin Wang, Limin Hao, Taixiang Saur, Katelyn Joyal, Ying Zhao, Desheng Zhai, Jie Li, Mochtar Pribadi, Giovanni Coppola, Bruce M Cohen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Unraveling Molecular Targets for Neurodegenerative Diseases ThroughInternational journal of molecular sciences · 2025
    Review
  2. A Brief Review on Caenorhabditis elegans Role in Modelling Neurodegenerative Disease.Central nervous system agents in medicinal chemistry · 2025
    Review
  3. Review
  4. Towards Understanding Neurodegenerative Diseases: Insights fromInternational journal of molecular sciences · 2023
    Review
  5. Biomolecules · 2023
    Review
  6. Review
  7. Review
  8. Where and Why Modeling Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2021
    Review
  9. Modeling neurodegeneration inDisease models & mechanisms · 2020
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Xin WangSchool of Public Health, Xinxiang Medical UniversityXinxiang, China; Program for Neuropsychiatric Research, McLean Hospital and Harvard Medical SchoolBelmont, MA, USA.
Limin HaoProgram for Neuropsychiatric Research, McLean Hospital and Harvard Medical School Belmont, MA, USA.
Taixiang SaurProgram for Neuropsychiatric Research, McLean Hospital and Harvard Medical School Belmont, MA, USA.
Katelyn JoyalProgram for Neuropsychiatric Research, McLean Hospital and Harvard Medical School Belmont, MA, USA.
Ying ZhaoSchool of Pharmacy, Xinxiang Medical University Xinxiang, China.
Desheng ZhaiProgram for Neuropsychiatric Research, McLean Hospital and Harvard Medical School Belmont, MA, USA.
Jie LiTianjin Mental Health Center Tianjin, China.
Mochtar PribadiSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
Giovanni CoppolaSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
Bruce M CohenProgram for Neuropsychiatric Research, McLean Hospital and Harvard Medical School Belmont, MA, USA.
Edgar A ButtnerProgram for Neuropsychiatric Research, McLean Hospital and Harvard Medical School Belmont, MA, USA.
Harvard University · USMcLean Hospital · USUniversity of California, Los Angeles · USXinxiang Medical University · CNTianjin Anding Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation associated with amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration (FTLD). Both

Indexed as

ACP2ALS-FTLDamyotrophic lateral sclerosisC9ORF72Caenorhabditis elegansVAPB

Identifiers

PMID27877110
PMCPMC5100550
OpenAlexW2553774328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.