ReviewNeuropsychiatric disease and treatment2016
Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis.
Review in Neuropsychiatric disease and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Anxiety prevalence among women with polycystic ovary syndrome in mainland China: a systematic review and meta-analysis.Frontiers in psychology · 2026Pooled it
- The prevalence and risk of anxiety and depression in polycystic ovary syndrome: an overview of systematic reviews with meta-analysis.Archives of women's mental health · 2025Pooled it
- Depression, anxiety and self-esteem in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Pooled it
- A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children.Translational psychiatry · 2021Pooled it
- Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic review.Journal of ovarian research · 2020Pooled it
- Nutrition Care and Dietetic Practice in Managing Metabolic and Endocrine Dysfunction in Polyendocrine Metabolic Ovarian Syndrome (PMOS): Implications and Opportunities in the Context of the Name Change of Polycystic Ovarian Syndrome to PMOS.Advances in nutrition (Bethesda, Md.) · 2026Review
- Stolen Femininity of Women with Polycystic Ovarian Syndrome: A Review.Oman medical journal · 2026Review
- A Pilot Study of the Role of Salivary Biomarkers in the Diagnosis of PCOS in Adolescents Across Different Body Weight Categories.Journal of clinical medicine · 2025Article
- Sirtuins, redox, and metabolic pathways in the brain of female PCOS mice.Journal of assisted reproduction and genetics · 2025Article
- Depression, anxiety, and stress in polycystic ovary syndrome: understanding the impact of adult separation anxiety and uncertainty intolerance.BMC women's health · 2025Article
- Suicide risk in persons with polycystic ovarian syndrome: a systematic review.Annals of general psychiatry · 2025Review
- Anti-infertility roles of flavonoids: insights into the female reproductive system.Molecular biology reports · 2025Review
- Uncovering the Hidden Connections Between PCOS and Alzheimer's Disease: A Two-Sample Mendelian Randomization Perspective.International journal of endocrinology and metabolism · 2025Article
- The association between meat consumption and polycystic ovary syndrome in Iranian women: a case-control study.BMC women's health · 2025Article
- Polycystic ovary syndrome and psychological distress: Urban-rural comparison among reproductive-aged women in Bangladesh.PLOS global public health · 2025Article
- Association of Polycystic Ovarian Syndrome Features and Metabolic Syndrome Among Reproductive-Aged Women in the United States.Women's health reports (New Rochelle, N.Y.) · 2025Article
- The Impact of the COVID-19 Pandemic on Health and Health Care Experience in Those With Polycystic Ovary Syndrome.International journal of women's health · 2025Article
- Psychological symptoms and brain activity alterations in women with PCOS and their relation to the reduced quality of life: a narrative review.Journal of endocrinological investigation · 2024Review
- Food Cravings and Obesity in Women with Polycystic Ovary Syndrome: Pathophysiological and Therapeutic Considerations.Nutrients · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between depression, anxiety, and polycystic ovary syndrome (PCOS) is still unclear. Therefore, a systematic review and meta-analysis was conducted to assess the rates of comorbid psychiatric disorders among women with PCOS compared to women without it.
methodsPubMed/MEDLINE, Embase, PsycINFO, and Web of Science databases were searched from inception to November 27, 2015. Studies were eligible for inclusion if they were original reports in which the rates of mood (bipolar disorder, dysthymia, or major depressive disorder), obsessive-compulsive spectrum disorders, trauma- and stressor-related disorders, anxiety disorders or psychotic disorders, somatic symptom and related disorders, or eating disorders had been investigated among women with an established diagnosis of PCOS and compared with women without PCOS. Psychiatric diagnosis should have been established by means of a structured diagnostic interview or through a validated screening tool. Data were extracted and pooled using random effects models.
resultsSix studies were included in the meta-analysis; of these, five reported the rates of anxiety and six provided data on the rates of depression. The rate of subjects with anxiety symptoms was higher in patients with PCOS compared to women without PCOS (odds ratio (OR) =2.76; 95% confidence interval (CI) 1.26 to 6.02; Log OR =1.013;
conclusionAnxiety and depression symptoms are more prevalent in patients with PCOS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.