ArticleInternational journal of chronic obstructive pulmonary disease2016
The association between inhaled corticosteroid and pneumonia in COPD patients: the improvement of patients' life quality with COPD in Taiwan (IMPACT) study.
Article in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD.European respiratory review : an official journal of the European Respiratory Society · 2021Pooled it
- Intraclass Difference in Pneumonia Risk with Fluticasone and Budesonide in COPD: A Systematic Review of Evidence from Direct-Comparison Studies.International journal of chronic obstructive pulmonary disease · 2020Pooled it
- Inhaled corticosteroids for bronchiectasis.The Cochrane database of systematic reviews · 2018Pooled it
- Inhaled Corticosteroids and Risk ofJournal of clinical medicine · 2025Article
- Response to the Letter to the Editor Regarding "Intraclass Difference in Pneumonia Risk with Fluticasone and Budesonide in COPD: A Systematic Review of Evidence from Direct-Comparison Studies" [Response to Letter].International journal of chronic obstructive pulmonary disease · 2021Article
- Risk of active tuberculosis among COPD patients treated with fixed combinations of long-acting beta2 agonists and inhaled corticosteroids.BMC infectious diseases · 2020Observational
- Risk of Pneumonia Associated with Inhaled Corticosteroid in Patients with Chronic Obstructive Pulmonary Disease: A Korean Population-Based Study.International journal of chronic obstructive pulmonary disease · 2020Article
- Article
- The Impact of Sepsis on the Outcomes of COPD Patients: A Population-Based Cohort Study.Journal of clinical medicine · 2018Article
- Inhaled corticosteroids in COPD: Personalising the therapeutic choice.African journal of thoracic and critical care medicine · 2018Review
- Low incidence of pneumonia in COPD patients treated with inhaled corticosteroids undergoing pulmonary rehabilitation.Clinical and molecular allergy : CMA · 2018Article
- Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2018Review
- Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the risk of pneumonia and severe exacerbations in patients with COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- Severe exacerbation and pneumonia in COPD patients treated with fixed combinations of inhaled corticosteroid and long-acting beta2 agonist.International journal of chronic obstructive pulmonary disease · 2017Observational
- Impact of selective and nonselective beta-blockers on the risk of severe exacerbations in patients with COPD.International journal of chronic obstructive pulmonary disease · 2017Article
- COPD patients prescribed inhaled corticosteroid in general practice: Based on disease characteristics according to guidelines?Chronic respiratory diseaseArticle
- Comparison of fluticasone propionate and budesonide on COPD macrophage and neutrophil function.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the association between inhaled corticosteroid (ICS) exposure patterns and the risk of pneumonia in chronic obstructive pulmonary disease (COPD) patients, we performed a nested case-control study. Between 1998 and 2010, 51,739 patients, including 19,838 cases of pneumonia, were matched to 74,849 control subjects selected from a cohort of COPD patients using ICSs via risk-set sampling of the database constructed by the National Health Research Institutes of Taiwan. After adjusting for covariates, the current use of ICSs was associated with a 25% increase in the risk of pneumonia (odds ratio [OR] =1.25, 95% confidence interval [CI] =1.20-1.30), and there was an increase in the OR with increase in the average daily dosage. Additionally, users of fluticasone/salmeterol, fluticasone, and either fluticasone/salmeterol or fluticasone were more likely to be at a higher risk of pneumonia (OR =1.35, 95% CI =1.28-1.41; OR =1.22, 95% CI =1.10-1.35; and OR =1.33, 95% CI =1.27-1.39, respectively). In contrast, there were no statistically significant associations between the risk of pneumonia and the use of budesonide/formoterol, budesonide, or either budesonide/formoterol or budesonide. In conclusion, ICSs are significantly associated with an increased risk of pneumonia in COPD patients. The effect is prominent for fluticasone-containing ICSs but not for budesonide-containing ICSs.
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