ArticleScientific reports2016
Stimulus-induced Epileptic Spike-Wave Discharges in Thalamocortical Model with Disinhibition.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 46 citations in OpenAlex.
- Striatum is the potential target for treating absence epilepsy: a theoretical evidence.Cognitive neurodynamics · 2024Article
- Spike-and-wave discharges of absence seizures in a sleep waves-constrained corticothalamic model.CNS neuroscience & therapeutics · 2024Article
- Phase synchronization and measure of criticality in a network of neural mass models.Scientific reports · 2022Article
- Drug Treatment of Progressive Myoclonic Epilepsy.Paediatric drugs · 2020Review
- Alpha rhythm slowing in a modified thalamo-cortico-thalamic model related with Alzheimer's disease.PloS one · 2020Article
- Detection of biological switches using the method of Gröebner bases.BMC bioinformatics · 2019Article
- Robust closed-loop control of spike-and-wave discharges in a thalamocortical computational model of absence epilepsy.Scientific reports · 2019Article
- Outgrowing seizures in Childhood Absence Epilepsy: time delays and bistability.Journal of computational neuroscience · 2019Article
- A new description of epileptic seizures based on dynamic analysis of a thalamocortical model.Scientific reports · 2017Article
- Prediction of the Seizure Suppression Effect by Electrical Stimulation via a Computational Modeling Approach.Frontiers in computational neuroscience · 2017Article
- Combined Effects of Feedforward Inhibition and Excitation in Thalamocortical Circuit on the Transitions of Epileptic Seizures.Frontiers in computational neuroscience · 2017Article
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3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Epileptic absence seizure characterized by the typical 2-4 Hz spike-wave discharges (SWD) are known to arise due to the physiologically abnormal interactions within the thalamocortical network. By introducing a second inhibitory neuronal population in the cortical system, here we propose a modified thalamocortical field model to mathematically describe the occurrences and transitions of SWD under the mutual functions between cortex and thalamus, as well as the disinhibitory modulations of SWD mediated by the two different inhibitory interneuronal populations. We first show that stimulation can induce the recurrent seizures of SWD in the modified model. Also, we demonstrate the existence of various types of firing states including the SWD. Moreover, we can identify the bistable parametric regions where the SWD can be both induced and terminated by stimulation perturbations applied in the background resting state. Interestingly, in the absence of stimulation disinhibitory functions between the two different interneuronal populations can also both initiate and abate the SWD, which suggests that the mechanism of disinhibition is comparable to the effect of stimulation in initiating and terminating the epileptic SWD. Hopefully, the obtained results can provide theoretical evidences in exploring dynamical mechanism of epileptic seizures.
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