ArticleScientific reports2016
Transcriptome profiling shows gene regulation patterns in ginsenoside pathway in response to methyl jasmonate in Panax Quinquefolium adventitious root.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 44 citations in OpenAlex.
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- Comprehensive Candidate Gene for Ginsenoside Rg1 Biosynthesis: Identification, Systematic Analysis, and Verification.Plants (Basel, Switzerland) · 2026Article
- Ginsenosides in Modern Pharmaceutics: Mechanisms, Applications, Challenges, and Perspectives.Biomolecules · 2026Review
- Sesquiterpene lactones in micropropagated Arnica montana shoots after elicitation-insights into metabolite accumulation and transcriptional regulation.Scientific reports · 2026Article
- Reprogramming Hairy Root Cultures: A Synthetic Biology Framework for Precision Metabolite Biosynthesis.Plants (Basel, Switzerland) · 2025Review
- Transcriptomic Analysis Under Drought and Salt Stress Provides Insight into Genes Putatively Involved in Ginsenoside Biosynthesis in Panax japonicus Meyer.Biochemical genetics · 2025Article
- Biotic Elicitors in Adventitious and Hairy Root Cultures: A Review from 2010 to 2022.Molecules (Basel, Switzerland) · 2022Review
- Network Pharmacology and Molecular Docking-Based Investigation of Potential Targets of Astragalus membranaceus and Angelica sinensis Compound Acting on Spinal Cord Injury.Disease markers · 2022Article
- Ginsenosides inActa pharmaceutica Sinica. B · 2021Review
- Article
- Planting Density AffectsFrontiers in plant science · 2021Article
- Till 2018: a survey of biomolecular sequences in genusJournal of ginseng research · 2020Review
- NAA and 6-BA promote accumulation of oleanolic acid by JA regulation in Achyranthes bidentata Bl.PloS one · 2020Article
- Transcriptomic profiling reveals MEP pathway contributing to ginsenoside biosynthesis in Panax ginseng.BMC genomics · 2019Article
- Postharvest UV-B Irradiation Stimulated Ginsenoside RgMolecules (Basel, Switzerland) · 2019Article
- Study on the Correlation between Gene Expression and Enzyme Activity of Seven Key Enzymes and Ginsenoside Content in Ginseng in Over Time in Ji'an, China.International journal of molecular sciences · 2017Article
- Transcriptome Analysis of Salicylic Acid Treatment inFrontiers in plant science · 2017Article
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Authors and funding
7 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Here, we combine elicitors and transcriptomics to investigate the inducible biosynthesis of the ginsenoside from the Panax quinquefolium. Treatment of P. quinquefolium adventitious root with methyl jasmonate (MJ) results in an increase in ginsenoside content (43.66 mg/g compared to 8.32 mg/g in control group). Therefore, we sequenced the transcriptome of native and MJ treated adventitious root in order to elucidate the key differentially expressed genes (DEGs) in the ginsenoside biosynthetic pathway. Through DEG analysis, we found that 5,759 unigenes were up-regulated and 6,389 unigenes down-regulated in response to MJ treatment. Several defense-related genes (48) were identified, participating in salicylic acid (SA), jasmonic acid (JA), nitric oxide (NO) and abscisic acid (ABA) signal pathway. Additionally, we mapped 72 unigenes to the ginsenoside biosynthetic pathway. Four cytochrome P450s (CYP450) were likely to catalyze hydroxylation at C-16 (c15743_g1, c39772_g1, c55422_g1) and C-30 (c52011_g1) of the triterpene backbone. UDP-xylose synthases (c52571_g3) was selected as the candidate, which was likely to involve in ginsenoside Rb
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