ArticleScientific reports2016
Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Bridging pleiotropic mechanisms in leprosy type-1 reactions and neurodegenerative diseases.Scientific reports · 2025Article
- Mitochondria inInternational journal of molecular sciences · 2022Review
- The ubiquitin ligation machinery in the defense against bacterial pathogens.EMBO reports · 2021Review
- Polymorphisms in mitochondrial ribosomal protein S5 (MRPS5) are associated with leprosy risk in Chinese.PLoS neglected tropical diseases · 2020Article
- Rare and novel variants of PRKN and PINK1 genes in Vietnamese patients with early-onset Parkinson's disease.Molecular genetics & genomic medicine · 2020Article
- Advances in the Immunology and Genetics of Leprosy.Frontiers in immunology · 2020Review
- Exploring the "Multiple-Hit Hypothesis" of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat.Frontiers in cellular and infection microbiology · 2019Review
- Polymorphisms in the TGFB1 and IL2RA genes are associated with clinical forms of leprosy in Brazilian population.Memorias do Instituto Oswaldo Cruz · 2018Article
- Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese.American journal of human genetics · 2018Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leprosy is a chronic infectious and neurological disease caused by Mycobacterium leprae, an unculturable pathogen with massive genomic decay and dependence on host metabolism. We hypothesized that mitochondrial genes PARL and PINK1 would confer risk to leprosy. Thirteen tag SNPs of PARL and PINK1 were analyzed in 3620 individuals with or without leprosy from China. We also sequenced the entire exons of PARL, PINK1 and PARK2 in 80 patients with a family history of leprosy by using the next generation sequencing technology (NGS). We found that PARL SNP rs12631031 conferred a risk to leprosy (P
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