Evidence map›Paper›PMID 27876822›Full record

ArticleNature communications2016

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.

Janina S Ried, Janina Jeff M, Audrey Y Chu, Jennifer L Bragg-Gresham, Jenny van Dongen, Jennifer E Huffman, Tarunveer S Ahluwalia, Gemma Cadby, Niina Eklund, Joel Eriksson and 266 more

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In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Multidimensional Bone Density Phenotyping Reveals New Insights Into Genetic Regulation of the Pediatric Skeleton.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

276 authors.

Janina S RiedInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Janina Jeff MThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Audrey Y ChuDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
Jennifer L Bragg-GreshamKidney Epidemiology and Cost Center, Internal Medicine-Nephrology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Jenny van DongenDepartment of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands.
Jennifer E HuffmanMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland.
Tarunveer S AhluwaliaFaculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
Gemma CadbyCentre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia 6009, Australia.
Niina EklundDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Joel ErikssonDepartment of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
Tõnu EskoBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 2142, USA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Anuj GoelDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0003-2307-4021
Mathias GorskiDepartment of Nephrology, University Hospital Regensburg, 93042 Regensburg, Germany.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland.
Nancy L Heard-CostaNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Anne U JacksonDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.ORCID 0000-0002-9672-2547
Eero JokinenHospital for Children and Adolescents, University of Helsinki, FI-00290 Helsinki, Finland.
Stavroula KanoniWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.
Kati KristianssonDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.ORCID 0000-0003-4688-107X
Zoltán KutalikSwiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Jari LahtiFolkhälsan Research Centre, FI-00290 Helsinki, Finland.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Carolina Medina-GomezDepartment of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.ORCID 0000-0001-7999-5538
Keri L MondaDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0001-5047-4077
Louis PérusseDepartment of Kinesiology, Laval University, Québec, Québec, Canada G1V 0A6.
Inga ProkopenkoWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0003-1624-7457
Lu QiDepartment of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
Erika SalviDepartment of Health Sciences, University of Milano at San Paolo Hospital, 20139 Milano, Italy.
Megan T SmithDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Alena StančákováDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Yun Ju SungDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Ioanna TachmazidouWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-8309-094X
Gudmar ThorleifssondeCODE Genetics, Amgen inc., 101 Reykjavik, Iceland.
Pim van der HarstDurrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands.
Ryan W WalkerThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Sophie R WangDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Sarah H WildCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, EH8 9AG Teviot Place, Edinburgh, Scotland.
Sara M WillemsDepartment of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
Andrew WongMRC Unit for Lifelong Health &Ageing at UCL, London WC1B 5JU, UK.ORCID 0000-0003-2079-4779
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Eva AlbrechtInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Alexessander Couto AlvesDepartment of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London W12 0NN, UK.
Stephan J L BakkerDepartment of Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands.
Cristina BarlassinaDepartment of Health Sciences, University of Milano at San Paolo Hospital, 20139 Milano, Italy.
Traci M BartzDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
John BeilbyPathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.ORCID 0000-0002-4915-2254
Claire BellisGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4001, Australia.
Richard N BergmanDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Sven BergmannSwiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.ORCID 0000-0002-6785-9034
John BlangeroSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas 78520, USA.
Matthias BlüherUniversity of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
Eric BoerwinkleHuman Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA.
Lori L BonnycastleMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Stefan R BornsteinMedical Faculty Carl Gustav Carus, Department of Medicine III, University of Dresden, 01307 Dresden, Germany.
Marcel BruinenbergUniversity of Groningen, University Medical Center Groningen, The LifeLines Cohort Study, 9700 RB Groningen, The Netherlands.
Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, EH8 9AG Teviot Place, Edinburgh, Scotland.
Yii-Der Ida ChenLos Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Charleston W K ChiangDepartment of Psychiatry, University of California, Los Angeles, California 90095, USA.
Peter S ChinesMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Fracensco CuccaUniversity of Sassari, 07100 Sassari, Italy.
L Adrienne CupplesNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Francesca D'AvilaDepartment of Health Sciences, University of Milano at San Paolo Hospital, 20139 Milano, Italy.
Eco J C de GeusDepartment of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands.
George DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 17671 Athens, Greece.
Maria DimitriouWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.
Angela DöringInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Johan G ErikssonFolkhälsan Research Centre, FI-00290 Helsinki, Finland.
Aliki-Eleni FarmakiDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 17671 Athens, Greece.
Martin FarrallDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Teresa FerreiraWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Krista FischerEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Nele FriedrichInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Anette Prior GjesingFaculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
Nicola GloriosoHypertension and Related Disease Centre, AOU-University of Sassari, 7100 Sassari, Italy.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Harald GrallertInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Niels GrarupFaculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
Jürgen GräßlerDepartment of Medicine III, Pathobiochemistry, Technische Universitaet, 01307 Dresden, Germany.
Jagvir GrewalDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Anders HamstenDepartment of Medicine, Karolinska Institutet, Stockholm, Sweden.
Marie Neergaard HarderFaculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
Catharina A HartmanUniversity of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion Regulation, 9700 RB Groningen, The Netherlands.
Maija HassinenKuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.
Nicholas HastieMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland.
Andrew Tym HattersleyInstitue of Biomedical &Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK.
Aki S HavulinnaDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Markku HeliövaaraDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Hans HillegeDepartment of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
Oddgeir HolmenDepartment of Public Health and General Practice, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
Jouke-Jan HottengaDepartment of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands.
Jennie HuiPathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.
Lise Lotte HusemoenResearch Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark.
Pirro G HysiDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Aaron IsaacsDepartment of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
Till IttermannInstitute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Shapour JalilzadehDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Alan L JamesDepartment of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia.
Torben JørgensenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Pekka JousilahtiDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Antti JulaDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Johanne Marie JustesenFaculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
Anne E JusticeDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland.
Maria KaraleftheriEchinos Medical Centre, 67300 Echinos, Greece.
Kay Tee KhawClinical Gerontology Unit, Box 251, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Sirkka M Keinanen-KiukaanniemiFaculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu F1-90014, Finland.
Leena KinnunenNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Paul B KnektDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Heikki A KoistinenNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Ivana KolcicDepartment of Public Health, Faculty of Medicine, University of Split, 21000 Split, Croatia.
Ishminder K KoonerEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Seppo KoskinenDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Peter KovacsUniversity of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
Theodosios KyriakouDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Tomi LaitinenKuopio University Hospital, 70029 Kuopio, Finland.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Alexandra M LewinDepartment of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London W12 0NN, UK.
Peter LichtnerInstitute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Cecilia M LindgrenBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 2142, USA.
Jaana LindströmDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Allan LinnebergResearch Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark.
Roberto LorbeerInstitute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Mattias LorentzonDepartment of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
Robert LubenStrangeways Research Laboratory Wort's Causeway, Cambridge CB1 8RN, UK.
Valeriya LyssenkoSteno Diabetes Center A/S, DK-2820 Gentofte, Denmark.
Satu MännistöDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Paolo ManuntaChair of Nephrology, Università Vita Salute San Raffaele and Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan 20139, Italy.
Irene Mateo LeachDepartment of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands.
Wendy L McArdleSchool of Social and Community Medicine, University of Bristol, Bristol BS82BN, UK.
Barbara McknightDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Evelin MihailovEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Rebecca MillsEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
May E MontasserDivision of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Gabriele MüllerCenter for Evidence Based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, 01307, Germany.
Arthur W MuskDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, West Australia 6009, Australia.
Narisu NarisuMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Ken K OngMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Ben A OostraDepartment of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
Clive OsmondMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.
Aarno PalotieInstitute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455-0381, USA.
Lavinia PaternosterMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK.
Brenda W PenninxDepartment of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, AJ Ernstraat 1887, 1081 HL Amsterdam, The Netherlands.
Irene PichlerCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.
Maria G PiliaIstituto di Ricerca Genetica e Biomedica, CNR, 9042 Monserrato, Italy.
Ozren PolašekCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, EH8 9AG Teviot Place, Edinburgh, Scotland.
Peter P PramstallerCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
D C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Nigel W RaynerWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Rasmus Ribel-MadsenFaculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Marcus RichardsOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
Kathy A RyanDivision of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Serena SannaIstituto di Ricerca Genetica e Biomedica, CNR, 9042 Monserrato, Italy.
Mark A SarzynskiHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
Salome ScholtensDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Sylvain SebertDepartment of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK.
Lorraine SouthamWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Thomas Hempel SparsøFaculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
Valgerdur SteinthorsdottirdeCODE Genetics, Amgen inc., 101 Reykjavik, Iceland.
Kathleen StirrupsWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.
Ronald P StolkDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Heather M StringhamDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Morris A SwertzDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Amy J SwiftMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Anke TönjesDepartment of Medicine, University of Leipzig, 04103 Leipzig, Germany.
Emmanouil TsafantakisAnogia Medical Centre, 74051 Anogia, Greece.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Jana V Van Vliet-OstaptchoukDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Liesbeth VandenputDepartment of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
Erkki VartiainenDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Cristina VenturiniDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Niek VerweijDepartment of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands.
Jorma S ViikariDepartment of Medicine, University of Turku, FI-20521 Turku, Finland.
Veronique VitartMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland.
Marie-Claude VohlInstitute of Nutrition and Functional Foods, Laval University, Québec, Québec, Canada G1V 0A6.
Judith M VonkDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Gérard WaeberDepartment of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
Elisabeth WidénInstitute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
Gonneke WillemsenDepartment of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands.
Tom WilsgaardDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway.
Thomas W WinklerDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93053 Regensburg, Germany.
Alan F WrightMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland.
Laura M Yerges-ArmstrongDivision of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
M Carola ZillikensDepartment of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
Daniele CusiDepartment of Health Sciences, University of Milano at San Paolo Hospital, 20139 Milano, Italy.
Ron T GansevoortDepartment of Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Torben HansenFaculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
Andrew A HicksCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.
Frank HuDepartment of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Kristian HveemDepartment of Public Health and General Practice, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
Marjo-Riitta JarvelinBiocenter Oulu, University of Oulu, Oulu FI-90014, Finland.
Eero KajantieDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Jaspal S KoonerEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Diana KuhMRC Unit for Lifelong Health &Ageing at UCL, London WC1B 5JU, UK.
Johanna KuusistoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Timo A LakkaKuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Inger NjølstadDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway.
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
Albertine J OldehinkelUniversity of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion Regulation, 9700 RB Groningen, The Netherlands.
Lyle J PalmerSchool of Public Health, University of Adelaide, Adelaide, South Australia 5005, Australia.
Oluf PedersenFaculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
Markus PerolaDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Bruce M PsatyCardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.
Hannu PuolijokiSouth Ostrobothnia Central Hospital, Seinäjoki Fi-60220, Finland.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, EH8 9AG Teviot Place, Edinburgh, Scotland.
Veikko SalomaaDepartment of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.
Peter E H SchwarzMedical Faculty Carl Gustav Carus, Department of Medicine III, University of Dresden, 01307 Dresden, Germany.
Alan R ShudinerDivision of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Jan H SmitDepartment of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, AJ Ernstraat 1887, 1081 HL Amsterdam, The Netherlands.
Thorkild I A SørensenFaculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.
Timothy D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Kari StefanssondeCODE Genetics, Amgen inc., 101 Reykjavik, Iceland.
Michael StumvollUniversity of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
Angelo TremblayDepartment of Kinesiology, Laval University, Québec, Québec, Canada G1V 0A6.
Jaakko TuomilehtoDiabetes Prevention Unit, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
André G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
Matti UusitupaDepartment of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
Peter VollenweiderDepartment of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Hugh WatkinsDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
James F WilsonMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland.
Eleftheria ZegginiWellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.
Goncalo R AbecasisDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Michael BoehnkeDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Ingrid B BoreckiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Cornelia M van DuijnDepartment of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
Caroline FoxNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Leif C GroopLund University Diabetes Centre and Department of Clinical Science, Diabetes &Endocrinology Unit, Lund University, 221 00 Malmö, Sweden.
Iris M HeidDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93053 Regensburg, Germany.
David J HunterBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 2142, USA.
Robert C KaplanDepartment of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Mark I McCarthyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Kari E NorthDepartment of Epidemiology, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA.
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
David SchlessingerNational Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
Unnur ThorsteinsdottirdeCODE Genetics, Amgen inc., 101 Reykjavik, Iceland.
David P StrachanPopulation Health Research Institute, St George's, University of London, London SW17 0RE, UK.ORCID 0000-0001-7854-1366
Timothy FraylingGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Joel N HirschhornBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 2142, USA.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Genetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2M
Department of Health NF-SI-0611-10219Medical Research Council G0601261Medical Research Council MC_PC_U127561128Medical Research Council MC_U147574242Medical Research Council MC_UP_A620_1016Medical Research Council MC_UU_12011/3Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12019/1Medical Research Council MR/J012165/1Medical Research Council MR/M013138/1NCATS NIH HHS UL1 TR000124NCI NIH HHS UM1 CA182913NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL163262NHLBI NIH HHS U01 HL130114NICHD NIH HHS P2C HD050924NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370Wellcome Trust 098395
6 · The paper itself

Abstract

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.

Indexed as

AnthropometryBody SizeModels, GeneticPrincipal Component AnalysisGenome-Wide Association StudyGenotypeHumans

Identifiers

PMID27876822
PMCPMC5114527

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