ReviewEuropean journal of clinical nutrition2017
Cold-induced thermogenesis in humans.
Review in European journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of Acute Heat and Cold Exposures at Rest or during Exercise on Subsequent Energy Intake: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Activation of Human Brown Adipose Tissue by Capsinoids, Catechins, Ephedrine, and Other Dietary Components: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Experimental hypothermia by cold air: a randomized, double-blind, placebo-controlled crossover trial.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Trial
- Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity.The Journal of clinical endocrinology and metabolism · 2019Trial
- Fasting and glucose induced thermogenesis in response to three ambient temperatures: a randomized crossover trial in the metabolic syndrome.European journal of clinical nutrition · 2018Trial
- Trial
- Women exhibit different thermoregulatory responses to meal and cold stimuli compared to men independently of energy expenditure and body composition.European journal of nutrition · 2026Article
- Comprehensive Analysis of miRNAs, mRNAs, and lncRNAs in Intestines of Breast- and Formula-Fed Pigs.Journal of animal physiology and animal nutrition · 2026Article
- Deuterium metabolic imaging beyond the brain: mapping tissue metabolism across the body.Magma (New York, N.Y.) · 2026Review
- Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction.Nature communications · 2026Article
- Review
- Hypothermia drives fatty acid transporter 1 upregulation and lipid accumulation in renal tubules: evidence from forensic cases.International journal of legal medicine · 2025Article
- Mitochondrial uncoupling, energy substrate utilization, and brown adipose tissue as therapeutic targets in cancer.npj metabolic health and disease · 2025Review
- A consensus guide to preclinical indirect calorimetry experiments.Nature metabolism · 2025Review
- Biochemical markers of cell death: Forensic implications for differentiating primary and secondary hypothermia.Open veterinary journal · 2025Article
- Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease.Nature reviews. Immunology · 2024Review
- Energy expenditure during physical work in cold environments: physiology and performance considerations for military service members.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- Article
- The thermoneutral zone in women takes an "arctic" shift compared to men.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Identifying hypothermia death in a mouse model by ATR-FTIR.International journal of legal medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
A basic property of endothermic thermoregulation is the ability to generate heat by increasing metabolism in response to cold ambient temperatures to maintain a stable core body temperature. This process, known as cold-induced thermogenesis (CIT), has been measured in humans as early as 1780 by Antoine Lavoisier, but has found renewed interest because of the recent 'rediscovery' of thermogenic, cold-activated brown adipose tissue (BAT) in adult humans. In this review, we summarize some of the key findings of the work involving CIT over the past two centuries and highlight some of the seminal studies focused on this topic. There has been a substantial range of variability in the reported CIT in these studies, from 0 to 280% above basal metabolism. We identify and discuss several potential sources of this variability, including both methodological (measurement device, cold exposure temperature and duration) and biological (age and body composition of subject population) discrepancies. These factors should be considered when measuring CIT going forward to better assess whether BAT or other thermogenic organs are viable targets to combat chronic positive energy balance based on their relative capacities to elevate human metabolism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.