ArticleContemporary clinical trials2017
The Starting Treatment for Ethanol in Primary care Trials (STEP Trials): Protocol for Three Parallel Multi-Site Stepped Care Effectiveness Studies for Unhealthy Alcohol Use in HIV-Positive Patients.
Article in Contemporary clinical trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01410123 (Integrated Stepped Care for Unhealthy Alcohol Use in HIV), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integrated Stepped Care for Unhealthy Alcohol Use in HIV
Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Integrated stepped alcohol treatment for patients with HIV and at-risk alcohol use: a randomized trial.Addiction science & clinical practice · 2020Trial
- Integrated stepped alcohol treatment for patients with HIV and liver disease: A randomized trial.Journal of substance abuse treatment · 2019Trial
- Interventions to Reduce Unhealthy Alcohol Use among Primary Care Patients with HIV: the Health and Motivation Randomized Clinical Trial.Journal of general internal medicine · 2019Trial
- Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial.The lancet. HIV · 2019Trial
- Intervention for alcohol use disorders at an HIV care clinic in Harare: a pilot and feasibility study.Addiction science & clinical practice · 2019Trial
- Article
- Integrating stakeholder feedback into the design of a peer-delivered primary care wellness program: A rapid qualitative study.BMC health services research · 2023Article
- Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population.Addiction science & clinical practice · 2023Article
- Perspectives on contingency management for alcohol use and alcohol-associated conditions among people in care with HIV.Alcohol, clinical & experimental research · 2023Article
- Contingency management with stepped care for unhealthy alcohol use among individuals with HIV: Protocol for a randomized controlled trial.Contemporary clinical trials · 2023Article
- Increasing Use of Video Telehealth Among Veterans Experiencing Homelessness with Substance Use Disorder: Design of A Peer-Led Intervention.Journal of technology in behavioral science · 2022Article
- Practices, attitudes, and confidence related to tobacco treatment interventions in HIV clinics: a multisite cross-sectional survey.Translational behavioral medicine · 2022Article
- The Relationship Between Drinking Behavior and Conversational Processes During a Brief Alcohol Reduction Intervention for People with HIV.AIDS and behavior · 2022Article
- Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV.AIDS and behavior · 2022Article
- A SMARTTT approach to Treating Tobacco use disorder in persons with HIV (SMARTTT): Rationale and design for a hybrid type 1 effectiveness-implementation study.Contemporary clinical trials · 2021Article
- Association of Social and Behavioral Risk Factors With Mortality Among US Veterans With COVID-19.JAMA network open · 2021Article
- Validating Self-Reported Unhealthy Alcohol Use With Phosphatidylethanol (PEth) Among Patients With HIV.Alcoholism, clinical and experimental research · 2020Article
- Predictors of initiation of and retention on medications for alcohol use disorder among people living with and without HIV.Journal of substance abuse treatment · 2020Article
- Low levels of initiation, engagement, and retention in substance use disorder treatment including pharmacotherapy among HIV-infected and uninfected veterans.Journal of substance abuse treatment · 2019Article
- Racial/ethnic differences in the association between alcohol use and mortality among men living with HIV.Addiction science & clinical practice · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 9 institutions in 1 country.
Funding
Abstract
Unhealthy alcohol use is common among HIV-positive patients, yet effective evidence-based treatments are rarely provided in clinical settings providing HIV care. Further, given patient variability in response to initial treatments, stepped care approaches may be beneficial. We describe the rationale, aims and study design for the current StartingTreatment forEthanol inPrimary care Trials (STEP Trials); three parallel randomized controlled effectiveness trials being conducted in five Infectious Disease Clinics. Participants meeting criteria for: 1) at-risk drinking, 2) moderate alcohol use with liver disease (MALD), or 3) alcohol use disorder (AUD) are randomized to integrated stepped care versus treatment as usual. For those with at-risk drinking or MALD, integrated stepped care starts with a one session brief intervention and follow-up 2-week telephone booster. Based on pre-specified nonresponse criteria, participants may be "stepped up" at week 4 to receive four sessions of motivational enhancement therapy (MET) and "stepped up" again at week 12 for addiction physician management (APM) and consideration of alcohol pharmacotherapy. For those with AUD, integrated stepped care begins with APM. Non-responders may be "stepped up" at week 4 to receive MET and again at week 12 for a higher level of care (e.g. intensive outpatient program). The primary outcome is alcohol consumption assessed at 24weeks, and secondary outcome is the VACS Index, a validated measure of HIV morbidity and mortality risk. Results from the STEP Trials should inform future research and the implementation of interventions to address unhealthy alcohol use among HIV-positive individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.