Evidence map›Paper›PMID 27876431›Full record

ArticleRenal failure2017

Cystatin C, vascular biomarkers and measured glomerular filtration rate in patients with unresponsive hypertensive phenotype: a pilot study.

Velibor Čabarkapa, Branislava Ilinčić, Mirjana Đerić, Viktorija Vučaj Ćirilović, Milena Kresoja, Radmila Žeravica, Vladimir Sakač

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Velibor Čabarkapaa Clinical Center of Vojvodina , Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia.
Branislava Ilinčića Clinical Center of Vojvodina , Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia.
Mirjana Đerića Clinical Center of Vojvodina , Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia.
Viktorija Vučaj Ćirilovića Clinical Center of Vojvodina , Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia.
Milena Kresojab Department of Mathematics and Informatics, Faculty of Sciences , University of Novi Sad , Novi Sad , Serbia.
Radmila Žeravicaa Clinical Center of Vojvodina , Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia.
Vladimir Sakača Clinical Center of Vojvodina , Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia.
University of Novi Sad · RSKlinički centar Vojvodine · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiomarkers are commonly used to estimate the presence of subclinical cardiovascular disease (CVD) in patients with essential arterial hypertension (HT). In addition to known association between cystatin C and glomerular filtration rate (GFR), elucidating the association between cystatin C and vascular biomarkers (intima-media thickness of common carotid arteries (CCIMT), carotid plaque and renal artery resistance index (RRI)) in patients with unresponsive hypertensive phenotype could be of significant clinical interest.

methodsParticipants (n = 200, median age 58 (52-64) years, 49% female) under treatment with antihypertensive drugs were stratified into two subgroups based on their blood pressure level as having responsive hypertension (RHT - compliant and responsive to treatment, n = 100), or nonresponsive (URHT - compliant but nonresponsive to treatment, n = 100). GFR was measured by isotopic (slope-intercept) method (99m Tc diethylene triamine penta-acetic acid - mGFR).

resultsThe URHT group had significantly higher median cystatin C serum concentration (p = 0.02) and CCIMT (p = 0.00) compared to the RHT group, with no significant difference in RRI (p = 0.51) and mGFR among subgroups [69.9 ± 28.2 vs 76.74 ± 23.61 ml/min/1.73m

conclusionIn addition to GFR, cystatin C serum concentration is positively and independently associated with CCIMT in patient with URHT phenotype and subclinical CVD. Prospective larger studies should further investigate the clinical importance of this relationship.

Indexed as

Carotid Intima-Media ThicknessGlomerular Filtration RateBiomarkersCreatinineCross-Sectional StudiesCystatin CEssential HypertensionFemaleHumansHypertensionMaleMiddle AgedPhenotypePilot ProjectsRegression AnalysisSerbiaBiomarkersCreatinineCystatin CBiomarkerscardiovascular riskcystatin Cessential hypertensionglomerular filtration ratesubclinical tissue organ damage

Identifiers

PMID27876431
PMCPMC6014334
OpenAlexW2549797046

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.