Evidence map›Paper›PMID 27876385›Full record

ArticleMechanisms of ageing and development2017

In old BALB/c mice, bone marrow pre-B cell and surrogate light chain reduction is associated with increased B cell reactivity to phosphorylcholine, but reduced T15 idiotype dominance.

Kelly Khomtchouk, Sarah Alter, Michelle Ratliff, Bonnie B Blomberg, Richard L Riley

Open access · greenAbstract read
In one paragraph

Article in Mechanisms of ageing and development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kelly KhomtchoukDepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, United States.
Sarah AlterDepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, United States.
Michelle RatliffDepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, United States.
Bonnie B BlombergDepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, United States.
Richard L RileyDepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, United States. Electronic address: rriley@med.miami.edu.
University of Miami · US

Funding

Regulation of Immunoglobulin Class Switch in Aged MiceR37AG023717 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BLOMBERG, BONNIE B. · 2005 to 2014
$3.3M
Selection of the B Cell Repertoire in SenescenceR01AG025256 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RILEY, RICHARD L · 2004 to 2016
$3.2M
How do obesity and related inflammation decrease antibody responses in aging?R01AG023717 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BLOMBERG, BONNIE B., FRASCA, DANIELA · 2017 to 2021
$1.8M
REGULATION OF SURROGATE LIGHT CHAIN IN AGED MICER01AG017618 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BLOMBERG, BONNIE B. · 2001 to 2005
$1.6M
NIA NIH HHS R01 AG017618NIA NIH HHS R01 AG023717NIA NIH HHS R01 AG025256NIA NIH HHS R37 AG023717
6 · The paper itself

Abstract

In young adult BALB/c mice, antibodies to phosphorylcholine (PC) bearing the T15 (TEPC 15) idiotype confer protection against pneumococcal infections. In old age, even though PC reactive B cells are often increased, the proportion of T15

Indexed as

AgingAnimalsAutoantibodiesBone Marrow CellsImmunoglobulin Light ChainsMiceMice, Inbred BALB CPhosphorylcholinePrecursor Cells, B-LymphoidReceptors, Antigen, B-CellSignal TransductionAutoantibodiesImmunoglobulin Light ChainsPhosphorylcholineReceptors, Antigen, B-CellAgingImmature B cellsPhosphorylcholinePre-B cell receptorSurrogate light chainT15 idiotype

Identifiers

PMID27876385
PMCPMC5381390
OpenAlexW2552575150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.