Evidence map›Paper›PMID 27876320›Full record

ArticleBioorganic & medicinal chemistry letters2016

Marine sponge alkaloids as a source of anti-bacterial adjuvants.

Roberta J Melander, Hong-Bing Liu, Matthew D Stephens, Carole A Bewley, Christian Melander

Abstract read
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 37 citations in OpenAlex.

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  7. Collagen- and hyaluronic acid-based hydrogels and their biomedical applications.Materials science & engineering. R, Reports : a review journal · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Roberta J MelanderDepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8024, United States.
Hong-Bing LiuLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, United States.
Matthew D StephensDepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8024, United States.
Carole A BewleyLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, United States.
Christian MelanderDepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8024, United States. Electronic address: ccmeland@ncsu.edu.
North Carolina State University · USNational Institutes of Health · US

Funding

Discovery, Structural Studies and Biosynthesis of Biologically Active Natural Products and Natural Product-Like InhibitorsZIADK031135 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BEWLEY, CAROLE · 2009 to 2025
$16.9M
SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
NMR STUDIES OF BACTERIAL REGULATORY PROTEINSR01GM055769 · NIGMS · WADSWORTH CENTER · PI CAVANAGH, JOHN, MELANDER, CHRISTIAN COREY · 1998 to 2017
$3.8M
NIDCR NIH HHS R01 DE022350NIGMS NIH HHS R01 GM055769
6 · The paper itself

Abstract

Novel approaches that do not rely upon developing microbicidal compounds are sorely needed to combat multidrug resistant (MDR) bacteria. The potential of marine secondary metabolites to serve as a source of non-traditional anti-bacterial agents is demonstrated by showing that pyrrole-imidazole alkaloids inhibit biofilm formation and suppress antibiotic resistance.

Indexed as

Acinetobacter baumanniiAlkaloidsAnimalsAnti-Bacterial AgentsDose-Response Relationship, DrugImidazolesMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular StructurePoriferaPyrrolesStructure-Activity RelationshipAlkaloidsAnti-Bacterial AgentsimidazoleImidazolesPyrrolesAdjuvantAntibioticBiofilmMarine spongePyrrole-imidazole alkaloid

Identifiers

PMID27876320
PMCPMC5776710
OpenAlexW2553658060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.