ArticleBioorganic & medicinal chemistry2017
Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,N'-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines.
Article in Bioorganic & medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Supramolecular Immobilization of Adamantyl and Carboxylate ModifiedMolecules (Basel, Switzerland) · 2022Article
- Discovery of Amide-Functionalized Benzimidazolium Salts as Potent α-Glucosidase Inhibitors.Molecules (Basel, Switzerland) · 2021Article
- Synthesis, characterization, in vitro SAR study, and preliminary in vivo toxicity evaluation of naphthylmethyl substituted bis-imidazolium salts.Bioorganic & medicinal chemistry · 2021Article
- Synthesis, characterization, and biological activity of a triphenylphosphonium-containing imidazolium salt against select bladder cancer cell lines.European journal of medicinal chemistry · 2020Article
- Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts.Molecules (Basel, Switzerland) · 2017Review
- Synthesis, characterization, in vitro SAR and in vivo evaluation of N,N'bisnaphthylmethyl 2-alkyl substituted imidazolium salts against NSCLC.Bioorganic & medicinal chemistry letters · 2017Article
- Synthesis, characterization, and in vitro SAR evaluation of N,N'-bis(arylmethyl)-CBioorganic & medicinal chemistry letters · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
A series of N,N'-bis(arylmethyl)benzimidazolium salts have been synthesized and evaluated for their in vitro anti-cancer activity against select non-small cell lung cancer cell lines to create a structure activity relationship profile. The results indicate that hydrophobic substituents on the salts increase the overall anti-proliferative activity. Our data confirms that naphthylmethyl substituents at the nitrogen atoms (N
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Registered trials
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