Evidence map›Paper›PMID 27876061›Full record

ArticleWorld journal of surgical oncology2016

Associations of DNMT3B -149C>T and -2437T>A polymorphisms and lung cancer risk in Chinese population.

Min Gao, Daqiang He, Fanji Meng, Jianing Li, Yan Shen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Min GaoDepartment of Neurology, the Fourth Hospital of Harbin Medical University, 37 Yiyuan Street, Harbin, Heilongjiang, 150001, China. gmingao@sina.com.
Daqiang HeDepartment of Radiology, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Fanji MengDepartment of Cardiology, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Jianing LiDepartment of Geriatrics, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Yan ShenDepartment of Geriatrics, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Fourth Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDNMT3B polymorphisms are associated with the susceptibility of lung cancer. DNMT3B -2437T>A is a novel polymorphism, and its influence on the risk of lung cancer in Chinese was investigated in this study. In addition, effect of DNMT3B -149C>T polymorphism on lung cancer was also explored.

methodsGenotyping in subjects were performed by PCR-RFLP. Haplotype frequencies were estimated by estimating haplotype software. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by unconditional logistic regression analysis.

resultsNeither of the two polymorphisms was correlated with lung cancer (-149C>T: CT+TT vs CC: OR = 0.78, 95%CI, 0.57 to 1.05, P = 0.361; -2437T>A: AT+AA vs TT: OR = 0.99, 95%CI, 0.74 to 1.33, P = 0.168). In stratification analysis, T-allele carrier genotype of -149C>T polymorphism resulted in a reduced lung cancer risk at stage II, compared with CC (OR = 0.46, 95%CI, 0.28 to 0.77, P = 0.023). In haplotype analysis, when -149C/-2437T was used as reference, the other combined genotypes of the two polymorphisms had no significant effect on lung cancer risk (P > 0.05).

conclusionsThe two DNMT3B polymorphisms are not correlated with lung cancer risk among Chinese population nor the haplotype of them.

Indexed as

Genetic Predisposition to DiseaseAgedAmplified Fragment Length Polymorphism AnalysisAsian PeopleCase-Control StudiesDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BFemaleGenotypeHaplotypesHumansLung NeoplasmsMaleMiddle AgedOdds RatioPolymorphism, Restriction Fragment LengthDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3B−149C>T−2437T>ADNMT3BLung cancerMethylationPolymorphism

Identifiers

PMID27876061
PMCPMC5118893
OpenAlexW2555106184

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.