ArticleBMC genomics2016
Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Regulatory networks involved in modulating fat deposition in pigs identified by gene co-expression analysis.BMC genomics · 2026Article
- Pig models reveal the interplay between fatty acids and cytokines in skeletal muscle.Scientific reports · 2025Article
- Putative epigenetic regulation mechanisms related to production, carcass and beef quality traits in Nelore cattle.Frontiers in genetics · 2025Article
- Novel putative causal mutations associated with fat traits in Nellore cattle uncovered by eQTLs located in open chromatin regions.Scientific reports · 2024Article
- Soybean molasses increases subcutaneous fat deposition while reducing lipid oxidation in the meat of castrated lambs.Journal of animal science · 2024Article
- RNA-seq transcriptome profiling of pigs' liver in response to diet with different sources of fatty acids.Frontiers in genetics · 2023Article
- Article
- Article
- EEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- Differential Gene Expression Associated with Soybean Oil Level in the Diet of Pigs.Animals : an open access journal from MDPI · 2022Article
- Article
- Integrative Analysis Between Genome-Wide Association Study and Expression Quantitative Trait Loci Reveals Bovine Muscle Gene Expression Regulatory Polymorphisms Associated With Intramuscular Fat and Backfat Thickness.Frontiers in genetics · 2022Article
- Multi-omic data integration for the study of production, carcass, and meat quality traits in Nellore cattle.Frontiers in genetics · 2022Article
- Fat Deposition in the Muscle of Female and Male Yak and the Correlation of Yak Meat Quality with Fat.Animals : an open access journal from MDPI · 2021Article
- Multi-Omics Approach Reveals miR-SNPs Affecting Muscle Fatty Acids Profile in Nelore Cattle.Genes · 2021Article
- Dynamic accumulation of fatty acids in duck (Anas platyrhynchos) breast muscle and its correlations with gene expression.BMC genomics · 2020Article
- Selection signatures in two oldest Russian native cattle breeds revealed using high-density single nucleotide polymorphism analysis.PloS one · 2020Article
- Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indicus.Scientific reports · 2019Article
- Comparative Analysis of the Liver Transcriptome among Cattle Breeds Using RNA-seq.Veterinary sciences · 2019Article
- Promoting the Outgrowth of Neurites on Electrospun Microfibers by Functionalization with Electrosprayed Microparticles of Fatty Acids.Angewandte Chemie (International ed. in English) · 2019Article
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Authors and funding
18 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipids are a class of molecules that play an important role in cellular structure and metabolism in all cell types. In the last few decades, it has been reported that long-chain fatty acids (FAs) are involved in several biological functions from transcriptional regulation to physiological processes. Several fatty acids have been both positively and negatively implicated in different biological processes in skeletal muscle and other tissues. To gain insight into biological processes associated with fatty acid content in skeletal muscle, the aim of the present study was to identify differentially expressed genes (DEGs) and functional pathways related to gene expression regulation associated with FA content in cattle.
resultsSkeletal muscle transcriptome analysis of 164 Nellore steers revealed no differentially expressed genes (DEGs, FDR 10%) for samples with extreme values for linoleic acid (LA) or stearic acid (SA), and only a few DEGs for eicosapentaenoic acid (EPA, 5 DEGs), docosahexaenoic acid (DHA, 4 DEGs) and palmitic acid (PA, 123 DEGs), while large numbers of DEGs were associated with oleic acid (OA, 1134 DEGs) and conjugated linoleic acid cis9 trans11 (CLA-c9t11, 872 DEGs). Functional annotation and functional enrichment from OA DEGs identified important genes, canonical pathways and upstream regulators such as SCD, PLIN5, UCP3, CPT1, CPT1B, oxidative phosphorylation mitochondrial dysfunction, PPARGC1A, and FOXO1. Two important genes associated with lipid metabolism, gene expression and cancer were identified as DEGs between animals with high and low CLA-c9t11, specifically, epidermal growth factor receptor (EGFR) and RNPS.
conclusionOnly two out of seven classes of molecules of FA studied were associated with large changes in the expression profile of skeletal muscle. OA and CLA-c9t11 content had significant effects on the expression level of genes related to important biological processes associated with oxidative phosphorylation, and cell growth, survival, and migration. These results contribute to our understanding of how some FAs modulate metabolism and may have protective health function.
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