Evidence map›Paper›PMID 27875802›Full record

Trial reportDrug and alcohol dependence2017

Urgency traits moderate daily relations between affect and drinking to intoxication among young adults.

Krysten W Bold, Lisa M Fucito, Kelly S DeMartini, Robert F Leeman, Henry R Kranzler, William R Corbin, Stephanie S O'Malley

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Alcohol and cannabis use predicted by affect-urgency interactions in everyday life.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  5. Review
  6. Article
  7. An experimental investigation into the effect of negative affect on the behavioral economic demand for alcohol.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Alcohol use in daily life: Examining the role of trait and state impulsivity facets.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Krysten W BoldYale School of Medicine, Department of Psychiatry, New Haven, CT, United States. Electronic address: krysten.bold@yale.edu.
Lisa M FucitoYale School of Medicine, Department of Psychiatry, New Haven, CT, United States; Yale Cancer Center, New Haven, CT, United States; Smilow Cancer Hospital at Yale-New Haven, New Haven, CT, United States.
Kelly S DeMartiniYale School of Medicine, Department of Psychiatry, New Haven, CT, United States; Smilow Cancer Hospital at Yale-New Haven, New Haven, CT, United States.
Robert F LeemanYale School of Medicine, Department of Psychiatry, New Haven, CT, United States; Univeristy of Florida, Department of Health Education and Behavior, Gainesville, FL, United States.
Henry R KranzlerPerelman School of Medicine, University of Pennsylvania and Crescenz VAMC, Philadelphia, PA, United States.
William R CorbinArizona State University, Department of Psychology, Tempe, AZ, United States.
Stephanie S O'MalleyYale School of Medicine, Department of Psychiatry, New Haven, CT, United States; Yale Cancer Center, New Haven, CT, United States.
Yale University · USArizona State University · USFlorida Department of Health · USPhiladelphia VA Medical Center · USSmilow Cancer Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Research Training Program in Substance Use PreventionT32DA019426 · NIDA · YALE UNIVERSITY · PI TAMI P SULLIVAN · 2005 to 2026
$7.5M
Naltrexone for Heavy Drinking in Young AdultsR01AA016621 · NIAAA · YALE UNIVERSITY · PI O'MALLEY, STEPHANIE S · 2007 to 2011
$3.0M
New Approaches to Smoking Cessation in Heavy DrinkersK23AA020000 · NIAAA · YALE UNIVERSITY · PI FUCITO, LISA M · 2011 to 2016
$755k
Difficulties with Self-Control and High-Risk Alcohol Use in Young AdultsK01AA019694 · NIAAA · YALE UNIVERSITY · PI LEEMAN, ROBERT F · 2010 to 2014
$705k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA019694NIAAA NIH HHS K23 AA020000NIAAA NIH HHS R01 AA016621NIDA NIH HHS T32 DA019426
6 · The paper itself

Abstract

backgroundYoung adults with higher trait urgency (i.e., a tendency to act rashly in response to heightened affect) may be especially vulnerable to heavy drinking. The current study examined 1) the influence of urgency on daily relations between affect and drinking to intoxication, and 2) whether urgency influenced the effectiveness of naltrexone (vs. placebo) for reducing alcohol use.

methodsThis study is a secondary analysis of data from 126 (n=40 female) heavy drinking young adults, ages 18-25, enrolled in a double-blind, 8-week clinical trial comparing brief motivational intervention and either naltrexone or placebo. Multilevel models examined whether trait urgency moderated daily relations between positive and negative affect and drinking to intoxication, measured by an estimated blood-alcohol concentration (eBAC) at or above the legal limit (≥0.08g%). Person-level interactions examined whether naltrexone was more effective than placebo at reducing the odds of eBAC≥0.08g% for individuals with higher vs. lower trait urgency.

resultsOn days of greater within-person positive or negative affect, young adults with higher urgency were more likely to drink to intoxication than those with lower urgency. Naltrexone reduced the odds of drinking to intoxication significantly more than placebo, independent of positive or negative urgency.

conclusionsAlthough naltrexone treatment reduced drinking overall, young adults with higher trait urgency were still at increased risk for hazardous drinking following times of strong positive or negative mood. Targeted interventions are needed to reduce the risk of heavy drinking among young adults with high trait urgency.

Indexed as

AdolescentAdultAffectAlcohol DrinkingAlcoholic IntoxicationDouble-Blind MethodFemaleHumansMaleMotivationNaltrexoneYoung AdultNaltrexoneAffectAlcoholDrinkingImpulsivityMoodUrgency

Identifiers

PMID27875802
PMCPMC5183550
OpenAlexW2546694559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.