ArticleEnvironmental research2017
Urinary phthalate and phthalate alternative metabolites and isoprostane among couples undergoing fertility treatment.
Article in Environmental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03733912 (To Investigate the Effect of Plasticizers on the Pregnancy in Vitro Fertilization Cycles), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
To Investigate the Effect of Plasticizers on the Pregnancy in Vitro Fertilization Cycles
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Phthalates exposure and attention-deficit/hyperactivity disorder in children: a systematic review of epidemiological literature.Environmental science and pollution research international · 2020Pooled it
- Integrated multi-omics analysis identifies TLR4-mediated mechanisms in ATBC-induced ovarian dysfunction and female infertility: A network toxicology, transcriptomic, and Mendelian randomization study.Journal of ovarian research · 2025Article
- Preconception Phthalate Exposure and Women's Reproductive Health: Pregnancy, Pregnancy Loss, and Underlying Mechanisms.Environmental health perspectives · 2023Article
- Exploring the internal exposome of seminal plasma with semen quality and live birth: A Pilot Study.Systems biology in reproductive medicine · 2023Article
- The Minderoo-Monaco Commission on Plastics and Human Health.Annals of global health · 2023Review
- Associations between mixtures of urinary phthalate metabolite concentrations and oxidative stress biomarkers among couples undergoing fertility treatment.Environmental research · 2022Article
- Association of Exposure to Phthalate Metabolites With Sex Hormones, Obesity, and Metabolic Syndrome in US Women.JAMA network open · 2022Article
- Phthalate and novel plasticizer concentrations in food items from U.S. fast food chains: a preliminary analysis.Journal of exposure science & environmental epidemiology · 2022Article
- Maternal Phthalates Exposure and Blood Pressure during and after Pregnancy in the PROGRESS Study.Environmental health perspectives · 2021Article
- Biomonitoring of volatile organic compounds (VOCs) among hairdressers in salons primarily serving women of color: A pilot study.Environment international · 2021Article
- Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico.Environment international · 2021Article
- Phthalate Exposure and Long-Term Epigenomic Consequences: A Review.Frontiers in genetics · 2020Review
- Phthalates and Phthalate Alternatives Have Diverse Associations with Oxidative Stress and Inflammation in Pregnant Women.Environmental science & technology · 2019Article
- Correlation and temporal variability of urinary biomarkers of chemicals among couples: Implications for reproductive epidemiological studies.Environment international · 2019Article
- Associations of urinary phthalate metabolites and lipid peroxidation with sperm mitochondrial DNA copy number and deletions.Environmental research · 2018Article
- Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration.Environmental science and pollution research international · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEpidemiological data suggest associations between phthalate exposures to a variety of adverse reproductive outcomes including reduced sperm quality and reproductive success. While mechanisms of these associations are not fully elucidated, oxidative stress has been implicated as a potential mediator. We examined associations of urinary metabolites of phthalates and phthalate alternative plasticizers with oxidative stress among couples seeking fertility treatment.
methodsSeventeen urinary plasticizer metabolites and 15-F2t isoprostane, a biomarker of oxidative stress, were quantified in spot samples from 50 couples seeking fertility treatment who enrolled in the Sperm Environmental Epigenetics and Development Study during 2014-2015.
resultsIn multivariable analyses, percent change in isoprostane was positively associated with interquartile range increases for the oxidative metabolites of di-2-ethylhexyl phthalate, [mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP; 20.0%, p=0.02), mono-2-ethyl-5-oxohexyl phthalate (MEOHP; 24.1%, p=0.01), and mono-2-ethyl-5-carboxypentyl phthalate (MECPP; 24.1%, p=0.004)], mono-isobutyl phthalate (MiBP; 17.8%, p=0.02), mono-hydroxyisobutyl phthalate (MHiBP; 27.5%, p=0.003), and cyclohexane-1,2-dicarboxylic acid mono-hydroxy-isononyl ester (MHINCH; 32.3%, p=0.002). Stratification of participants by sex revealed that isoprostane was positively associated with MHiBP (41.4%, p=0.01) and monocarboxy-isononyl phthalate (MCNP; 26.0%, p=0.02) among females and MEOHP (35.8%, p=0.03), MiBP (29.2%, p=0.01), MHiBP (34.7%, p=0.007) and MHINCH (49.0%, p=0.002) among males.
conclusionsOur results suggest that exposure to phthalates and phthalate replacements are associated with higher levels of oxidative stress in a sex-specific manner. Additional studies are needed to replicate our findings and to examine the potential health implications of the use of phthalates and alternative phthalates in consumer end products.
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Registered trials
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