ArticlePloS one2016
Reentry and Ectopic Pacemakers Emerge in a Three-Dimensional Model for a Slab of Cardiac Tissue with Diffuse Microfibrosis near the Percolation Threshold.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Ablation, percolation, and afterdepolarization.Biophysical journal · 2026Article
- Multiscale stochastic modeling for calcium dynamics in cardiac electrophysiology: assessing whole-cell model reliability under phosphorylation and LCC downregulation.Frontiers in network physiology · 2026Article
- 'Trapped re-entry' as source of acute focal atrial arrhythmias.Cardiovascular research · 2024Article
- The physics of heart rhythm disorders.Physics reports · 2022Article
- Critical Requirements for the Initiation of a Cardiac Arrhythmia in Rat Ventricle: How Many Myocytes?Cells · 2022Article
- Identifying locations susceptible to micro-anatomical reentry using a spatial network representation of atrial fibre maps.PloS one · 2022Article
- The Atrium in Atrial Fibrillation - A Clinical Review on How to Manage Atrial Fibrotic Substrates.Frontiers in cardiovascular medicine · 2022Review
- Multiparametric analysis of geometric features of fibrotic textures leading to cardiac arrhythmias.Scientific reports · 2021Article
- Article
- Machine Learning Identification of Pro-arrhythmic Structures in Cardiac Fibrosis.Frontiers in physiology · 2021Article
- 3D Electrophysiological Modeling of Interstitial Fibrosis Networks and Their Role in Ventricular Arrhythmias in Non-Ischemic Cardiomyopathy.IEEE transactions on bio-medical engineering · 2020Article
- Variability in electrophysiological properties and conducting obstacles controls re-entry risk in heterogeneous ischaemic tissue.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- An audit of uncertainty in multi-scale cardiac electrophysiology models.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Review
- Anisotropic conduction in the myocardium due to fibrosis: the effect of texture on wave propagation.Scientific reports · 2020Article
- Unified mechanism of local drivers in a percolation model of atrial fibrillation.Physical review. E · 2019Article
- Scar shape analysis and simulated electrical instabilities in a non-ischemic dilated cardiomyopathy patient cohort.PLoS computational biology · 2019Article
- Addressing challenges of quantitative methodologies and event interpretation in the study of atrial fibrillation.Computer methods and programs in biomedicine · 2019Review
- Self-organization of conducting pathways explains electrical wave propagation in cardiac tissues with high fraction of non-conducting cells.PLoS computational biology · 2019Article
- Ectopic beats arise from micro-reentries near infarct regions in simulations of a patient-specific heart model.Scientific reports · 2018Article
- Killing Many Birds With Two Stones: Hypoxia and Fibrosis Can Generate Ectopic Beats in a Human Ventricular Model.Frontiers in physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arrhythmias in cardiac tissue are generally associated with irregular electrical wave propagation in the heart. Cardiac tissue is formed by a discrete cell network, which is often heterogeneous. Recently, it was shown in simulations of two-dimensional (2D) discrete models of cardiac tissue that a wave crossing a fibrotic, heterogeneous region may produce reentry and transient or persistent ectopic activity provided the fraction of conducting connections is just above the percolation threshold. Here, we investigate the occurrence of these phenomena in three-dimensions by simulations of a discrete model representing a thin slab of cardiac tissue. This is motivated (i) by the necessity to study the relevance and properties of the percolation-related mechanism for the emergence of microreentries in three dimensions and (ii) by the fact that atrial tissue is quite thin in comparison with ventricular tissue. Here, we simplify the model by neglecting details of tissue anatomy, e. g. geometries of atria or ventricles and the anisotropy in the conductivity. Hence, our modeling study is confined to the investigation of the effect of the tissue thickness as well as to the comparison of the dynamics of electrical excitation in a 2D layer with the one in a 3D slab. Our results indicate a strong and non-trivial effect of the thickness even for thin tissue slabs on the probability of microreentries and ectopic beat generation. The strong correlation of the occurrence of microreentry with the percolation threshold reported earlier in 2D layers persists in 3D slabs. Finally, a qualitative agreement of 3D simulated electrograms in the fibrotic region with the experimentally observed complex fractional atrial electrograms (CFAE) as well as strong difference between simulated electrograms in 2D and 3D were found for the cases where reentry and ectopic activity were triggered by the micro-fibrotic region.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.