ArticlePloS one2016
Inescapable Stress Changes Walking Behavior in Flies - Learned Helplessness Revisited.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- On the nature of grief: uncovering the evolutionary roots of loss across the animal realm.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Exploring emotional expression in invertebrates: mechanisms, functions and phylogeny.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- When prediction fails: a computational complexity view of stress.Frontiers in veterinary science · 2026Article
- Review
- Article
- Choice, control, and animal welfare: definitions and essential inquiries to advance animal welfare science.Frontiers in veterinary science · 2023Review
- Regulation and modulation of biogenic amine neurotransmission inFrontiers in physiology · 2023Review
- Socioeconomic Status and Individual Personal Responsibility Beliefs Towards Food Access.Food ethics · 2022Article
- Excessive energy expenditure due to acute physical restraint disrupts Drosophila motivational feeding response.Scientific reports · 2021Article
- Anti-instinctive Learning Behavior Revealed by Locomotion-Triggered Mild Heat Stress inFrontiers in behavioral neuroscience · 2020Article
- Repeated Failure in Reward Pursuit Alters Innate Drosophila Larval Behaviors.Neuroscience bulletin · 2018Article
- A biphasic locomotor response to acute unsignaled high temperature exposure in Drosophila.PloS one · 2018Article
- Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment.Nature communications · 2017Article
- Discrete Serotonin Systems Mediate Memory Enhancement and Escape Latencies after Unpredicted Aversive Experience inFrontiers in systems neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Like other animals flies develop a state of learned helplessness in response to unescapable aversive events. To show this, two flies, one 'master', one 'yoked', are each confined to a dark, small chamber and exposed to the same sequence of mild electric shocks. Both receive these shocks when the master fly stops walking for more than a second. Behavior in the two animals is differently affected by the shocks. Yoked flies are transiently impaired in place learning and take longer than master flies to exit from the chamber towards light. After the treatment they walk more slowly and take fewer and shorter walking bouts. The low activity is attributed to the fly's experience that its escape response, an innate behavior to terminate the electric shocks, does not help anymore. Earlier studies using heat pulses instead of electric shocks had shown similar effects. This parallel supports the interpretation that it is the uncontrollability that induces the state.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.