ArticlePloS one2016
Short- and Long-Term Mortality Rates of Elderly Acute Kidney Injury Patients Who Underwent Continuous Renal Replacement Therapy.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Factors Associated with In-Hospital Mortality after Continuous Renal Replacement Therapy for Critically Ill Patients: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Clinical Characteristics and Outcomes in Patients Aged ≥80 Years Treated in the Intensive Care Units of a Large Multispecialty Metropolitan Hospital in Poland.Journal of clinical medicine · 2025Article
- Risk factors for short-term mortality in elderly critically ill AKI patients treated with CRRT in the ICU: a retrospective cohort study.BMC nephrology · 2025Article
- Age-stratified mortality and associated risk factors in adults aged 65 years or older undergoing continuous kidney replacement therapy: a consecutive retrospective study.BMC nephrology · 2025Article
- Prevention and Management of Perioperative Acute Kidney Injury: A Narrative Review.Diseases (Basel, Switzerland) · 2025Review
- Article
- Using machine learning to predict the risk of short-term and long-term death in acute kidney injury patients after commencing CRRT.BMC nephrology · 2024Article
- Mortality of elderly patients with acute kidney injury undergoing continuous renal replacement therapy: is age a risk factor?Kidney research and clinical practice · 2024Article
- Development and validation of a model for predicting in-hospital mortality in patients with sepsis-associated kidney injury receiving renal replacement therapy: a retrospective cohort study based on the MIMIC-IV database.Frontiers in cellular and infection microbiology · 2024Article
- Article
- A Clinical and Demographic Profile of Elderly (>65 Years) in the Medical Intensive Care Units of a Tertiary Care Center.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Clinical outcomes and prognostic factors of mortality in liver cirrhosis patients on continuous renal replacement therapy in two tertiary hospitals in Korea.Kidney research and clinical practice · 2021Article
- Acute kidney injury and aging.Pediatric nephrology (Berlin, Germany) · 2021Review
- Mortality predictors in critically ill patients with acute kidney injury requiring continuous renal replacement therapy.Kidney research and clinical practice · 2021Article
- Population Pharmacokinetic Modeling and Simulations of Imipenem in Burn Patients With and Without Continuous Venovenous Hemofiltration in the Military Health System.Journal of clinical pharmacology · 2021Article
- Epidemiology and outcomes of elderly patients requiring renal replacement therapy in the intensive care unit: an observational study.BMC nephrology · 2021Observational
- Continuous renal replacement therapy in elderly with acute kidney injury.The Korean journal of internal medicine · 2020Review
- Indoxyl sulfate is associated with mortality after AKI - more evidence needed!BMC nephrology · 2019Article
- Long-term outcomes in acute kidney injury patients who underwent continuous renal replacement therapy: a single-center experience.Clinical and experimental nephrology · 2018Article
- Clinical characteristics of sepsis-induced acute kidney injury in patients undergoing continuous renal replacement therapy.Renal failure · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe world's population is aging faster and the incidence of acute kidney injury (AKI) needing continuous renal replacement therapy (CRRT) is increasing in elderly population. The outcome of AKI needing CRRT in elderly patients is known to be poor. However, the definitions of elderly used in the previous literatures were diverse and, there were few data that compared the long-term mortality rates of these patients with middle aged patients. This study was aimed to evaluate this issue.
methodsThis study was a single-center, retrospective cohort study of patients who underwent CRRT from January 2013 to December 2015. The patients were divided into the following four age cohorts: middle-aged (55-64), young-old (65-74), middle-old (75-84), and old-old (≥85). The short- and long-term mortality rates for each age cohort were compared.
resultsA total of 562 patients met the inclusion criteria. The short-term mortality rate was 57.3% in the entire cohort. Compared with the middle-aged cohort, the middle-old cohort (HR 1.48 (1.09-2.02), p = 0.012) and the old-old cohort (HR 2.33 (1.30-4.19), p = 0.005) showed an increased short-term mortality rate along with an increased SOFA score, acidemia and a prolonged prothrombin time. When we analyzed the long-term mortality rate of the 238 survived patients, the middle-old cohort (HR 3.76 (1.84-7.68), p<0.001), the old-old cohort (HR 4.40(1.20-16.10), p = 0.025), a lower BMI, the presence of liver cirrhosis, the presence of congestive heart failure and a history of sepsis were independent risk factors for the prediction of long-term mortality.
conclusionCompared with the middle-aged cohort, the middle-old and the old-old cohort showed an increased short-term and long-term mortality rate. However, in the young-old cohort, neither the short-term nor the long-term mortality rate was increased.
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