Evidence map›Paper›PMID 27875379›Full record

ReviewCurrent opinion in psychiatry2017

The decision neuroscience perspective on suicidal behavior: evidence and hypotheses.

Alexandre Y Dombrovski, Michael N Hallquist

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. When Losses Matter More: A Dynamic Reference-Dependent Evaluation of Suicide Risk.Risk analysis : an official publication of the Society for Risk Analysis · 2026
    Article
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  8. Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025
    Review
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  15. Impact ofJournal of clinical medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Alexandre Y DombrovskiaUniversity of Pittsburgh, Department of Psychiatry, Pittsburgh bPenn State University, Department of Psychology, State College, Pennsylvania, USA.
Michael N Hallquist
Pennsylvania State University · USUniversity of Pittsburgh · US

Funding

Short Term Variability in Affect and Rest Activity Rhythms in Long Term Chronic and Highly Variable Suicidal Ideation in Depressed Older AdultsR01MH085651 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANGA CSILLA GALFALVY, Swathi Gujral · 2010 to 2026
$9.6M
Reward Learning in Late-Life Suicidal BehaviorR01MH100095 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Alexandre Y. Dombrovski · 2014 to 2026
$6.8M
Neurocomputational studies of mood-related momentum dynamics linking reward learning, valuation and responsivityR01MH124092 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOMBROVSKI, ALEXANDRE Y., ELDAR, ERAN PLAYFAIR · 2020 to 2024
$5.3M
Cognitive and Affective Neuroscience of Decision-Making in Late-Life SuicideK23MH086620 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOMBROVSKI, ALEXANDRE Y. · 2009 to 2013
$853k
Neurodevelopmental Origins of Emotion Dysregulation in Borderline PersonalityK01MH097091 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HALLQUIST, MICHAEL NELSON · 2013 to 2016
$620k
Screening For Inhibitors of Bacterial Capsule BiogenesisR03MH090791 · NIMH · DUKE UNIVERSITY · PI SEED, PATRICK C. · 2010 to 2011
$78k
NIMH NIH HHS K01 MH097091NIMH NIH HHS K23 MH086620NIMH NIH HHS R01 MH085651NIMH NIH HHS R01 MH100095NIMH NIH HHS R01 MH124092NIMH NIH HHS R03 MH090791
6 · The paper itself

Abstract

purpose of reviewSuicide attempts are usually regretted by people who survive them. Furthermore, addiction and gambling are over-represented among people who attempt or die by suicide, raising the question whether their decision-making is impaired. Advances in decision neuroscience have enabled us to investigate decision processes in suicidal people and to elucidate putative neural substrates of disadvantageous decision-making. RECENT

findingsEarly studies have linked attempted suicide to poor performance on gambling tasks. More recently, functional MRI augmented with a reinforcement learning computational model revealed that impaired decision-making in suicide attempters is paralleled by disrupted expected value (expected reward) signals in the ventromedial prefrontal cortex. Behavioral studies have linked increased delay discounting to low-lethality/poorly planned attempts, multiple attempts, and the co-occurrence of attempted suicide and addiction. This behavioral tendency may be related to altered integrity of the basal ganglia. By contrast, well-planned, serious suicide attempts were associated with intact/diminished delay discounting. One study has linked high-lethality suicide attempts and impaired social decision-making. SUMMARY: This emerging literature supports the notion that various impairments in decision-making - often broadly related to impulsivity - may mark different pathways to suicide. We propose that aggressive and self-destructive responses to social stressors in people prone to suicide result from a predominance of automatic, Pavlovian processes over goal-directed computations.

Indexed as

Suicide, AttemptedDecision MakingHumans

Identifiers

PMID27875379
PMCPMC5291285
OpenAlexW2553902797

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.