ArticleJPEN. Journal of parenteral and enteral nutrition2018
Biochemical Markers of Nutrition Support in Critically Ill Trauma Victims.
Article in JPEN. Journal of parenteral and enteral nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Long-term postdischarge immunonutrition management in elective colorectal cancer surgery patients an interim analysis of a Chinese multicenter randomised controlled trial.Metabolism open · 2026Article
- Impact of nutritional screening on mortality and intensive care unit length of stay.Frontiers in nutrition · 2025Article
- Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction.Journal of geriatric cardiology : JGC · 2024Article
- Factors Associated with Nutritional Risk Assessment in Critically Ill Patients Using the Malnutrition Universal Screening Tool (MUST).Journal of clinical medicine · 2024Article
- Evaluation of plasma prealbumin as a novel inflammatory biomarker in dogs: a pilot study.Frontiers in veterinary science · 2023Article
- Observational study to assess the relationship between enteral nutrition delivery and nutritional biomarkers among mechanically ventilated critically ill patients.Saudi journal of biological sciences · 2022Article
- Prealbumin as a nutrition status indicator may be associated with outcomes of geriatric hip fractures: a propensity score matching and 1-year follow-up study.Aging clinical and experimental research · 2022Article
- Fractional Gluconeogenesis: A Biomarker of Dietary Energy Adequacy in a Rat Brain Injury Model.Metabolites · 2022Article
- Effect of Early Enteral Nutrition Support Combined with Chemotherapy on Related Complications and Immune Function of Patients after Radical Gastrectomy.Journal of healthcare engineering · 2022Article
- Biomarkers in critical care nutrition.Critical care (London, England) · 2020Review
- Transthyretin at Admission and Over Time as a Marker for Clinical Outcomes in Critically Ill Trauma Patients: A Prospective Single-Center Study.World journal of surgery · 2020Observational
- The malnutrition in polytrauma patients (MaPP) study: Research protocol.Nutrition and health · 2019Article
- Increasing Enteral Protein Intake in Critically Ill Trauma and Surgical Patients.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2019Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIn critically ill patients, plasma serum albumin and transthyretin concentrations are thought to reflect the effects of acute illness, including resuscitation and inflammation. Their use as markers for preexisting nutrition status is, therefore, not recommended. Whether they can be used to assess subsequent effectiveness of artificial nutrition support is unclear. We sought to determine if these biomarkers are associated with enteral caloric intake in critically ill trauma patients. MATERIALS AND
methodsWe analyzed data from adult trauma victims who required ≥2 days of mechanical ventilation and ≥7 days of intensive care. We categorized patients into low, middle, or high enteral calorie delivery groups (2, 9, or 17 kcal/kg/d during the first week). We compared serial concentrations of serum albumin, transthyretin, and C-reactive protein. Multiple linear and Poisson regression were used to determine relationships between calorie intake and nutrition biomarkers.
resultsIn total, 1056 patients were analyzed. Their median age was 44 (interquartile range [IQR], 28-57) years, and median injury severity score was 34 (IQR, 26-41). Calorie intake during the first week was not related to biomarkers during the first or second week. However, by the beginning of the third week, the highest calorie group showed greater changes in concentrations of transthyretin (+3.0 mg/dL relative to initial concentration, P = .01) and serum albumin (+0.17 g/dL, P = .05) compared with the lowest calorie group.
conclusionsIn trauma patients requiring 1 or more weeks of intensive care, changes in transthyretin were associated with enteral caloric intake. Our data suggest that transthyretin could be used to monitor nutrition support after 2 weeks in intensive care.
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