ArticleProceedings of the National Academy of Sciences of the United States of America1989
An alternative cytoplasmic domain of the integrin beta 3 subunit.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 121 citations in OpenAlex.
- Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication.Biochimica et biophysica acta · 2008Article
- Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.Journal of cell science · 2008Article
- Disruption of C-terminal cytoplasmic domain of betaPS integrin subunit has dominant negative properties in developing Drosophila.Molecular biology of the cell · 2002Article
- Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding.The Biochemical journal · 2001Article
- beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter.Molecular and cellular biology · 2001Article
- Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart development.The Journal of cell biology · 1998Article
- Identification of beta1C-2, a novel variant of the integrin beta1 subunit generated by utilization of an alternative splice acceptor site in exon C.The Biochemical journal · 1998Article
- The laminin-binding activity of the alpha 7 integrin receptor is defined by developmentally regulated splicing in the extracellular domain.Molecular biology of the cell · 1997Article
- Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells.The Journal of cell biology · 1996Article
- Beta 1 integrin-dependent and -independent polymerization of fibronectin.The Journal of cell biology · 1996Article
- A splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans.The Journal of cell biology · 1995Article
- Identification of a novel form of the alpha 3 integrin subunit: covalent association with transferrin receptor.The Biochemical journal · 1995Article
- Human microvascular endothelial cell-extracellular matrix interaction in cellular growth state determination.Cell and tissue research · 1995Article
- Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility.The Journal of cell biology · 1994Article
- Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly.The Journal of cell biology · 1994Article
- Regulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages.Molecular biology of the cell · 1994Article
- A new alternative transcript encodes a 60 kDa truncated form of integrin beta 3.The Biochemical journal · 1994Article
- Integrin cytoplasmic domains mediate inside-out signal transduction.The Journal of cell biology · 1994Article
- Integrins: cell adhesives and modulators of cell function.The Histochemical journal · 1993Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A cDNA encoding a new form of the shared beta subunit (beta 3) of the platelet integrin gpIIb/IIIa and the vitronectin receptor was isolated from a placental cDNA library by screening with a beta 3 (gpIIIa) DNA probe. This beta 3 variant differs from the previously reported beta 3 in that the cytoplasmic domain is 8 amino acids shorter and has an alternative, 13-amino acid COOH-terminal peptide. The 3' untranslated region of the cDNA also differs from the previously reported sequence, while the region coding for the transmembrane domain and extracellular domain is identical to it. Reverse transcription combined with polymerase chain reaction was used to show that human placental tissue and two human cell lines contain the variant mRNA. The sequences of the cDNAs for the previously known beta 3 and the variant beta 3 described here suggest that the difference between the cytoplasmic domains of these subunits arises as a result of an alternative mRNA splicing. These cytoplasmic domains may provide alternative means for the beta 3 integrins to interact with cytoskeletal components.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.