Evidence map›Paper›PMID 27874907›Full record

ReviewNatural product reports2017

Natural products as mediators of disease.

Neha Garg, Tal Luzzatto-Knaan, Alexey V Melnik, Andrés Mauricio Caraballo-Rodríguez, Dimitrios J Floros, Daniel Petras, Rachel Gregor, Pieter C Dorrestein, Vanessa V Phelan

Abstract readReview
In one paragraph

Review in Natural product reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Phytochemicals in Drug Discovery-A Confluence of Tradition and Innovation.International journal of molecular sciences · 2024
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. The Role of Oral Microbiota in Intra-Oral Halitosis.Journal of clinical medicine · 2020
    Review
  15. Inhibitory Effects of Eriodictyol-7-Molecules (Basel, Switzerland) · 2020
    Article
  16. Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  17. Review
  18. Review
  19. Surface-Enhanced Raman Scattering Spectroscopy for Label-Free Analysis ofFrontiers in cellular and infection microbiology · 2018
    Review
  20. Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline.Angewandte Chemie (International ed. in English) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Neha GargCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, CA 92093, USA. pdorrestein@ucsd.edu vanessa.phelan@ucdenver.edu.
Tal Luzzatto-Knaan
Alexey V Melnik
Andrés Mauricio Caraballo-Rodríguez
Dimitrios J Floros
Daniel Petras
Rachel Gregor
Pieter C Dorrestein
Vanessa V Phelan

Funding

The Interactive Metabolome of Polymicrobial BiofilmsK01GM103809 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PHELAN, VANESSA V · 2012 to 2016
$647k
NIGMS NIH HHS K01 GM103809
6 · The paper itself

Abstract

Covering: up to 2016Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

Indexed as

Biological ProductsHumansMicrobiotaMolecular StructureBiological Products

Identifiers

PMID27874907
PMCPMC5299058

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.