Evidence map›Paper›PMID 27874898›Full record

ArticleThe Analyst2016

Polymer-mediated ternary supramolecular interactions for sensitive detection of peptides.

Mahalia A C Serrano, Huan He, Bo Zhao, Rajasekhar R Ramireddy, Richard W Vachet, S Thayumanavan

Abstract read
In one paragraph

Article in The Analyst, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Absolute Quantitation of Oxidizable Peptides by Coulometric Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mahalia A C SerranoDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003-9336, USA. rwvachet@chem.umass.edu thai@chem.umass.edu.
Huan HeDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003-9336, USA. rwvachet@chem.umass.edu thai@chem.umass.edu.
Bo ZhaoDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003-9336, USA. rwvachet@chem.umass.edu thai@chem.umass.edu.
Rajasekhar R RamireddyDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003-9336, USA. rwvachet@chem.umass.edu thai@chem.umass.edu.
Richard W VachetDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003-9336, USA. rwvachet@chem.umass.edu thai@chem.umass.edu.
S ThayumanavanDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003-9336, USA. rwvachet@chem.umass.edu thai@chem.umass.edu.

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
Supramolecular Assemblies for Detecting Biomarkers in Complex MixturesR01CA169140 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THAYUMANAVAN, SANKARAN · 2013 to 2017
$1.7M
NCI NIH HHS R01 CA169140NIGMS NIH HHS T32 GM008515
6 · The paper itself

Abstract

A combination of donor-acceptor and electrostatic interactions in a three-component supramolecular system has been shown to form the basis for selective and sensitive detection of peptides. Different substituents in the polymer and the detection matrix were compared to demonstrate that the favorable donor-acceptor interactions explain the observed signal enhancement. The ternary supramolecular interactions discovered in this work are enabled by the self-packing behavior of amphiphilic homopolymers and their ability to mediate interactions between the detection matrix and peptide that facilitate sensitive detection of peptides.

Indexed as

Chemistry Techniques, AnalyticalHydrophobic and Hydrophilic InteractionsLimit of DetectionPeptidesPolymersStatic ElectricityPeptidesPolymers

Identifiers

PMID27874898
PMCPMC5167624

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.